Recombinant Mouse PTPN6 Protein (aa 207-597, His & GST tag)
#
-
Catalog numberPKSM040450-20µg
-
Price:
-
Size20µg
-
-
Synonym70Z-SHP;hcp;Hcph;me;Ptp1C;PTPTY-42;SH-PTP1;SHP-1
-
ActivityMeasured by its ability to dephosphorylate a phosphotyrosine residue in an EGF receptor 988998 phosphopeptide substrate, R&D Systems, Catalog # ES006.The specific activity is > 4 μmoles/min/μg.
-
SequenceAla207-Lys597
-
Fusion tagN-His & GST
-
AccessionP29351-2
-
Expressed HostBaculovirus-Insect Cells
-
ShippingIn general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
-
Purity> 85 % as determined by SDS-PAGE
-
Endotoxin< 1.0 EU per μg of the protein as determined by the LAL method
-
Stability and StorageSamples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Mol Mass72.7 kDa
-
AP Mol Mass63 kDa
-
FormulationLyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.0, 10% glycerol
-
BackgroundPTPN6 is an enzyme which belongs to the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of PTPN6 contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of PTPN6 with its substrates. PTPN6 is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. It has been shown that PTPN6 interacts with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling.
-
Conjugationhistidine
-
TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
-
Latin nameMus musculus
-
SourceRecombinants or rec. proteins
-
Grouprecombinants
-
Gene target
-
Gene symbolMGST3, MIR597, PTPN6
-
Short nameRecombinant Mouse PTPN6 Protein (aa 207-597, His & GST tag)
-
TechniqueRecombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
-
Hostmouse
-
LabelHis
-
SpeciesMouse, Mouses
-
Alternative nameRec. Mouse protein tyrosine phosphatase, non-receptor classification 6 Protein (aa 207-597, histidine & GST detection labelled)
-
Alternative techniquerec, murine
-
Alternative to gene targetprotein tyrosine phosphatase, non-receptor type 6, HCP and HCPH and HPTP1C and PTP-1C and SH-PTP1 and SHP-1 and SHP-1L and SHP1, PTPN6 and IDBG-15719 and ENSG00000111679 and 5777, SH2 domain binding, nuclei, Ptpn6 and IDBG-187635 and ENSMUSG00000004266 and 15170, PTPN6 and IDBG-640141 and ENSBTAG00000020294 and 512312
-
Gene info
-
Identity
-
Gene
-
Long gene namemicrosomal glutathione S-transferase 3
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1997-10-16
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Microsomal glutathione S-transferases
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namemicroRNA 597
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year2006-05-16
-
Entrez gene record
-
RefSeq identity
-
Classification
- MicroRNAs
Gene info
-
Identity
-
Gene
-
Long gene nameprotein tyrosine phosphatase non-receptor type 6
-
Synonyms
-
Locus
-
Discovery year1992-02-12
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Protein tyrosine phosphatases non-receptor type
- SH2 domain containing
-
VEGA ID
MeSH Data
-
Name
-
ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
-
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data