Recombinant Mouse PSMA / FOLH1 Protein (His tag)

• Catalog number
  PKSM040800-10µg
• Price
  Please ask
• Size
  10µg

• Synonym
  GCP2;mopsm
• Activity
  NA
• Sequence
  Ile 44-Ala 752
• Fusion tag
  N-His
• Accession
  NP_058050.3
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  > 88 % as determined by SDS-PAGE
• Endotoxin
  < 1.0 EU per μg of the protein as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  81.8 kDa
• AP Mol Mass
  100-110 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  Glutamate carboxypeptidase 2, also known as Glutamate carboxypeptidase II, Membrane glutamate carboxypeptidase, Prostate-specific membrane antigen, GCPII, PSMA, FOLH1, and NAALAD1, is a single-pass type I I membrane protein which belongs to the peptidase M28 family and M28B subfamily. FOLH1 is highly expressed in prostate epithelium. It is detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon, brain (at protein level), and the capillary endothelium of a variety of tumors. FOLH1 has both folate hydrolase and N-acetylated alpha linked acidic dipeptidase (NAALADase) activity. It has a preference for tri-alpha-glutamate peptides. Genetic variation in FOLH1 may be associated with low folate levels and consequent hyperhomocysteinemia. This condition can result in increased risk of cardiovascular disease, neural tube defects, and cognitive deficits. FOLH1 also shows a promising role in directed imaging and therapy of recurrent or metastatic disease.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy
• Technical data
• Conjugation
  histidine
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  PSMA   FOLH1   Protein   His   tag  
• Gene symbol
  FOLH1
• Short name
  Recombinant Mouse PSMA / FOLH1 Protein (His tag)
• Technique
  Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Host
  mouse
• Label
  His
• Species
  Mouse, Mouses
• Alternative name
  Rec. Mouse PSMA / FOLH1 Protein (histidine detection labelled)
• Alternative technique
  rec, murine

Gene info

• Identity
  HGNC:3788
• Gene
  FOLH1
• Long gene name
  folate hydrolase 1
• Synonyms gene
  • FOLH
• Synonyms gene name
  • folate hydrolase (prostate-specific membrane antigen) 1
• Synonyms
  • PSM
  • PSMA
  • NAALAD1
  • NAALAdase
  • GCP2
  • GCPII
• Synonyms name
  • glutamate carboxylase II
  • glutamate carboxypeptidase 2
• GenBank acession
  • M99487
• Locus
  11p11.12
• Discovery year
  1996-12-16
• Entrez gene record
  2346
• Pubmed identfication
  • 9838072
• RefSeq identity
  • NM_004476
• Classification
  • M28 metallopeptidases
• VEGA ID
  OTTHUMG00000166625

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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