Recombinant Mouse IL1R1 / CD121a Protein (Fc tag)
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Catalog number
PKSM040478-50µg
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Price
Please ask
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Size
50µg
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Synonym
CD121a;CD121b;IL-1R1;IL-iR;Il1r-1
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Activity
1. Measured by its binding ability in a functional ELISA.2. Immobilized recombinant human IL1b at 10 μg/mL (100 μl/well) can mouse IL1R1-Fc with a linear range of 62.5-1000 ng/mL.
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Sequence
Met 1-Lys 338
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Fusion tag
C-Fc
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Accession
P13504
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Expressed Host
HEK293 Cells
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Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
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Purity
> 92 % as determined by SDS-PAGE
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Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
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Stability and Storage
Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Mol Mass
64.3 kDa
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AP Mol Mass
70 kDa
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Formulation
Lyophilized from sterile PBS, pH 7.4
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Background
Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokine induced immune and inflammatory responses. This protein has been characterized by pharmacological and molecular techniques in the mouse brain. The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1β activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1β induced effects. In the spleen, a slight increase in IL-1R AcP and IL-1R1 was observed during the first hours following LPS stimulation. In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess.
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Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin name
Mus musculus
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
IL1R1-AS1, IL1R1
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Short name
Recombinant Mouse IL1R1 / CD121a Protein (Fc tag)
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Technique
Recombinant, Mouse, FC, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
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Host
mouse
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Label
Fc Tag
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Species
Mouse, Mouses
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Alternative name
Rec. Mouse interleukin 1 receptor, classification I / CD121a Protein (fragment c detection labelled)
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Alternative technique
rec, murine
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Alternative to gene target
interleukin 1 receptor, type I, CD121A and D2S1473 and IL-1R-alpha and IL1R and IL1RA and P80, IL1R1 and IDBG-64088 and ENSG00000115594 and 3554, interleukin-1, Extracellular, Il1r1 and IDBG-148254 and ENSMUSG00000026072 and 16177, IL1R1 and IDBG-630765 and ENSBTAG00000005273 and 515640
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Gene info
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Identity
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Gene
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Long gene name
IL1R1 antisense RNA 1
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Synonyms
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Locus
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Discovery year
2018-05-16
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Pubmed identfication
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Classification
Gene info
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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