Recombinant Mouse DDR1 Kinase / MCK10 / CD167 Protein (His tag)
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Catalog number
PKSM040462-50µg
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Price
Please ask
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Size
50µg
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Synonym
6030432F18;AI323681;Cak;CD167a;Nep;PTK3A
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Activity
NA
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Sequence
Met 1-Thr 414
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Fusion tag
C-His
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Accession
NP_766550.1
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Expressed Host
HEK293 Cells
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Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
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Purity
> 95 % as determined by SDS-PAGE
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Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
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Stability and Storage
Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Mol Mass
45.4 kDa
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AP Mol Mass
50 kDa
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Formulation
Lyophilized from sterile PBS, pH 7.4
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Background
Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of DDR1/MCK10/CD167 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. DDR1/MCK10/CD167 plays an important role in regulating attachment to collagen, chemotaxis, proliferation, and MMP production in smooth muscle cells. DDR1 functions in a feedforward loop to increase p53 levels and at least some of its effectors. Inhibition of DDR1 function resulted in strikingly increased apoptosis of wild-type p53-containing cells in response to genotoxic stress through a caspase-dependent pathway.
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Conjugation
histidine
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Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin name
Mus musculus
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
DDR1, DDR1-DT
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Short name
Recombinant Mouse DDR1 Kinase / MCK10 / CD167 Protein (His tag)
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Technique
Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
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Host
mouse
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Label
His
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Species
Mouse, Mouses
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Alternative name
Rec. Mouse discoidin domain receptor tyrosine kinase 1 phosphorylation catalyst / MCK10 / CD167 Protein (histidine detection labelled)
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Alternative technique
rec, murine
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Alternative to gene target
discoidin domain receptor tyrosine kinase 1, CAK and CD167 and DDR and EDDR1 and HGK2 and MCK10 and NEP and NTRK4 and PTK3 and PTK3A and RTK6 and TRKE, DDR1 and IDBG-76157 and ENSG00000204580 and 100616237,780, transferase activity, Extracellular, Ddr1 and IDBG-178873 and ENSMUSG00000003534 and 12305, DDR1 and IDBG-634478 and ENSBTAG00000010682 and 534092
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Gene info
Gene info
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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