Recombinant Mouse CD69 / CLEC2C / AIM Protein (His tag, ECD)
-
Catalog number
PKSM040513-20µg
-
Price
Please ask
-
Size
20µg
-
-
Synonym
5830438K24Rik;AI452015;AIM;VEA
-
Activity
NA
-
Sequence
Asn62-Arg199
-
Fusion tag
C-His
-
Accession
NP_001028294.1
-
Expressed Host
HEK293 Cells
-
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
-
Purity
> 85 % as determined by SDS-PAGE.
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Stability and Storage
Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Mol Mass
17.3 kDa
-
AP Mol Mass
17.3 kDa
-
Formulation
Lyophilized from sterile PBS, pH 7.4
-
Background
Early activation antigen CD69, also known as activation inducer molecule (AIM), is a single-pass type II membrane protein. Recently, cDNA clones encoding human and mouse CD69 were isolated and showed CD69 to be a member of the C-type lectin superfamily. It is one of the earliest cell surface antigens expressed by T cells following activation. Once expressed, CD69 acts as a costimulatory molecule for T cell activation and proliferation. In addition to mature T cells, CD69 is inducibly expressed by immature thymocytes, B cells, natural killer (NK) cells, monocytes, neutrophils and eosinophils, and is constitutively expressed by mature thymocytes and platelets. CD69 is involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets. The structure, chromosomal localization, expression and function of CD69 suggest that it is likely a pleiotropic immune regulator , potentially important in the activation and differentiation of a wide variety of hematopoietic cells. This membrane molecule transiently expresses on activated lymphocytes, and its selective expression in inflammatory infiltrates suggests that it plays a role in the pathogenesis of inflammatory diseases. CD69 plays a crucial role in the pathogenesis of allergen-induced eosinophilic airway inflammation and hyperresponsiveness and that CD69 could be a possible therapeutic target for asthmatic patients.
-
-
Conjugation
histidine
-
Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
-
Latin name
Mus musculus
-
Source
Recombinants or rec. proteins
-
Group
recombinants
-
Gene target
-
Gene symbol
CD69, ECD, SLC45A2, AURKB, SEM1
-
Short name
Recombinant Mouse CD69 / CLEC2C / AIM Protein (His tag, ECD)
-
Technique
Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
-
Host
mouse
-
Label
His
-
Species
Mouse, Mouses
-
Alternative name
Rec. Mouse CD69 molecule / CLEC2C / AIM Protein (histidine detection labelled, ECD)
-
Alternative technique
rec, murine
-
Alternative to gene target
CD69 molecule, AIM and BL-AC/P26 and CLEC2C and EA1 and GP32/28 and MLR-3, CD69 and IDBG-18077 and ENSG00000110848 and 969, carbohydrate binding, Cell surfaces, Cd69 and IDBG-191849 and ENSMUSG00000030156 and 12515, CD69 and IDBG-639618 and ENSBTAG00000002135 and 281058
-
Gene info
-
Identity
-
Gene
-
Long gene name
CD69 molecule
-
Synonyms gene name
- CD69 antigen (p60, early T-cell activation antigen)
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year
1992-08-06
-
Entrez gene record
-
Pubmed identfication
-
Classification
- C-type lectin domain containing
- CD molecules
-
VEGA ID
Gene info
Gene info
Gene info
-
Identity
-
Gene
-
Long gene name
aurora kinase B
-
Synonyms gene
-
Synonyms gene name
- serine/threonine kinase 12
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year
1999-01-29
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Chromosomal passenger complex
- Protein phosphatase 1 regulatory subunits
-
VEGA ID
Gene info
MeSH Data
-
Name
-
Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
-
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
-
Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
Similar products
