Recombinant Mouse CADM4 / IGSF4C / TSLL2 Protein (His tag)

• Catalog number
  PKSM040646-50µg
• Price
  Please ask
• Size
  50µg

• Synonym
  Igdf4c;Igsf4c;Tsll2
• Activity
  NA
• Sequence
  Met 1-Ala 324
• Fusion tag
  C-His
• Accession
  NP_694752.1
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  > 97 % as determined by SDS-PAGE
• Endotoxin
  < 1.0 EU per μg of the protein as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  34.5 kDa
• AP Mol Mass
  50-60 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  Immunoglobulin superfamily member 4C (IGSF4C), also known as CADM4 or NECL-4, is an immunoglobulin (Ig) superfamily molecule showing significant homology with a lung tumor suppressor, TSLC1. CADM4/IGSF4C/NECL-4 protein is mainly expressed in the kidney, bladder, and prostate in addition to the brain. Experiments have reported the biological significance of CADM4/IGSF4C/NECL-4 in the urinary tissues. An immunohistochemical study reveals that CADM4 is expressed at the cell-cell attachment sites in the renal tubules, the transitional epithelia of the bladder, and the glandular epithelia of the prostate. IGSF4-immunoreactivity (IR) was observed diffusely in the telencephalic wall, whereas it became rather confined to the subplate, the cortical plate and the subventricular zone as the development proceeded. IGSF4-IR gradually decreased after birth and disappeared in adulthood. IGSF4 remained at low levels throughout embryonic stage, whereas it increased after birth. These spatiotemporal patterns of the expression suggest that IGSF4 plays crucial roles in the development of both telencephalon and cerebellum. CADM4/IGSF4C/NECL-4 is ectopically expressed in adult T-cell leukemia (ATL) cells, providing not only a diagnostic marker for ATL, but also a possible therapeutic target against its invasion. The distinct roles of CADM4/IGSF4C/NECL-4 in the oncogenesis of carcinomas and ATL could be due to tissue-specific differences in the downstream cascades, and is a novel concept with respect to cell adhesion in human oncogenesis.
• Technical data
• Conjugation
  histidine
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CADM4   IGSF4C   TSLL2   Protein   His   tag  
• Gene symbol
  CADM4
• Short name
  Recombinant Mouse CADM4 / IGSF4C / TSLL2 Protein (His tag)
• Technique
  Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Host
  mouse
• Label
  His
• Species
  Mouse, Mouses
• Alternative name
  Rec. Mouse cellular adhesion molecule 4 / IGSF4C / TSLL2 Protein (histidine detection labelled)
• Alternative technique
  rec, murine
• Alternative to gene target
  cell adhesion molecule 4, CADM4 and IDBG-55399 and ENSG00000105767 and 199731, protein binding, Plasma membranes, Cadm4 and IDBG-154862 and ENSMUSG00000054793 and 260299, CADM4 and IDBG-639102 and ENSBTAG00000015984 and 523277

Gene info

• Identity
  HGNC:30825
• Gene
  CADM4
• Long gene name
  cell adhesion molecule 4
• Synonyms gene
  • IGSF4C
• Synonyms gene name
  • immunoglobulin superfamily, member 4C
• Synonyms
  • TSLL2
  • Necl-4
  • SynCAM4
• Synonyms name
  • nectin-like 4
• GenBank acession
  • AF363368
• Locus
  19q13.31
• Discovery year
  2004-02-24
• Entrez gene record
  199731
• Pubmed identfication
  • 11536053
• RefSeq identity
  • NM_145296
• Classification
  • C2-set domain containing
  • V-set domain containing
  • Nectins and nectin-like molecules
• VEGA ID
  OTTHUMG00000182735

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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