Recombinant Mouse Autotaxin / ENPP2 / NPP2 Protein (His tag) 20µg
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Catalog number
PKSM040556-20µg
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Price
Please ask
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Size
20µg
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Activity
NA
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Synonym
ATX;E-NPP 2;lysoPLD;Npps2;PD-Ialpha;Pdnp2
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Sequence
Ser 49-Ile 862
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Fusion tag
N-His
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Accession
Q9R1E6-1
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Expressed Host
HEK293 Cells
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Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
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Purity
> 93 % as determined by SDS-PAGE
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Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
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Stability and Storage
Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Mol Mass
96 kDa
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AP Mol Mass
55-75 kDa
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Formulation
Lyophilized from sterile 20mM Tris, 150mM NaCl, pH 7.4
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Background
ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2), also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene. This gene product stimulates the motility of tumor cells, has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The Autotaxin protein is important for generating the lipid signaling molecule lysophosphatidic acid (LPA), which is a potent mitogen, which facilitates cell proliferation and migration, neurite retraction, platelet aggregation, smooth muscle contraction, actin stress formation and cytokine and chemokine secretion. ATX has been found to catalyze the formation of cyclic phosphatidic acid (cPA), which have antitumor role by antimitogenic regulation of cell cycle, inhibition of cancer invasion and metastasis. LPA receptors and ATX are upregulated in numerous cancer cell types and show expression patterns that correlate with tumor cell invasiveness. Thus, Autotaxin has recently emerged as an attractive target for the development of anti-cancer chemotherapeutics. In addition, Serum ATX activity was found to be enhanced in relation to hepatic fibrosis in chronic liver disease due to hepatitis virus C infection.
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Conjugation
histidine
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Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin name
Mus musculus
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
ENPP2
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Short name
Recombinant Mouse Autotaxin / ENPP2 / NPP2 Protein (His tag) 20µg
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Technique
Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
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Host
mouse
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Label
His
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Species
Mouse, Mouses
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Alternative name
Rec. Mouse Autotaxin / ectonucleotide pyrophosphatase/phosphodiesterase 2 / NPP2 Protein (histidine detection labelled) 20µg
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Alternative technique
rec, murine
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Alternative to gene target
ectonucleotide pyrophosphatase/phosphodiesterase 2, ATX and ATX-X and AUTOTAXIN and LysoPLD and NPP2 and PD-IALPHA and PDNP2, ENPP2 and IDBG-33807 and ENSG00000136960 and 5168, alkylglycerophosphoethanolamine phosphodiesterase activity, Extracellular, Enpp2 and IDBG-140731 and ENSMUSG00000022425 and 18606, ENPP2 and IDBG-645628 and ENSBTAG00000013165 and 532663
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Gene info
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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