Recombinant Mouse ACVR2B Protein (His & Fc tag) 100µg

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• Catalog number
  PKSM040826-100µg
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• Size
  100µg

# #

• Activity
  1. Measured by its ability to bind biotinylated Human INHBA-his in functional ELISA.2. Measured by its ability to bind biotinylated mouse INHBA-his in functional ELISA.3. Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is typically 10-50 ng/mL in the presence of 10 ng/mL recombinant Activin A.
• Synonym
  4930516B21Rik;ActRIIB
• Sequence
  Met 1-Thr 134
• Fusion tag
  C-His & Fc
• Accession
  NP_031423.1
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  > 97 % as determined by SDS-PAGE
• Endotoxin
  < 1.0 EU per μg of the protein as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  41 kDa
• AP Mol Mass
  60-65 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of skeletal muscle growth, is regarded as a potential therapeutic target and binds to ACVR2B effectively, and to a lesser extent, to ACVR2A. The structure of human ACVR2B kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other catalytic kinase domains. Haplotype structure at the ACVR2B and follistatin loci may contribute to interindividual variation in skeletal muscle mass and strength. Defects in ACVR2B are a cause of left-right axis malformations.
• Technical data
• Conjugation
  histidine
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• Source
  Recombinants or rec. proteins
• Group
  recombinants

#

• Gene target
  ACVR2B   Protein   His   tag   100µg  
• Gene symbol
  ACVR2B-AS1, ACVR2B
• Short name
  Recombinant Mouse ACVR2B Protein (His & Fc tag) 100µg
• Technique
  Recombinant, Mouse, FC, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Host
  mouse
• Label
  His
• Species
  Mouse, Mouses
• Alternative name
  Rec. Mouse ACVR2B Protein (histidine & fragment c detection labelled) 100µg
• Alternative technique
  rec, murine

Gene info

• Identity
  HGNC:44161
• Gene
  ACVR2B-AS1
• Long gene name
  ACVR2B antisense RNA 1
• Synonyms gene name
  • ACVR2B antisense RNA 1 (non-protein coding)
• GenBank acession
  • AK025619
• Locus
  3p22.2
• Discovery year
  2012-06-30
• Entrez gene record
  100128640
• RefSeq identity
  • NR_028389
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000156031

Gene info

• Identity
  HGNC:174
• Gene
  ACVR2B
• Long gene name
  activin A receptor type 2B
• Synonyms gene name
  • activin A receptor, type IIB
• Synonyms
  • ActR-IIB
• GenBank acession
  • X77533
• Locus
  3p22.2
• Discovery year
  1997-03-19
• Entrez gene record
  93
• Pubmed identfication
  • 8161782
  • 9621519
• RefSeq identity
  • NM_001106
• Classification
  • Type 2 receptor serine/threonine kinases
• VEGA ID
  OTTHUMG00000131291

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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