Recombinant Mouse α-Synuclein/SNCA Protein(N-6His) 50µg

• Catalog number
  PKSM041186-50µg
• Price
  Please ask
• Size
  50µg

• Activity
  NA
• Synonym
  Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP; Snca
• Sequence
  Met1-Ala140
• Fusion tag
  N-6His
• Accession
  O55042
• Expressed Host
  E.coli
• Shipping
  The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
• Purity
  ＞95% as determined by reducing SDS-PAGE.
• Stability and Storage
  Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
• Mol Mass
  15.9 kDa
• AP Mol Mass
  18 kDa
• Formulation
  Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Background
  Alpha-synuclein (Snca) belongs to a family of proteins including a-, b-, and g-synucleins. Alpha-synuclein has been found to be implicated in the pathophysiology of many neurodegenerative diseases, including Parkinson's disease (PD) and Alzheimer's disease. Manyneurodegenerative diseases has shown that alpha-synuclein accumulates in dystrophic neurites and in Lewy bodies. The function of alpha-synuclein is closely correlated with its three-dimensional structure, especially for proteins important in the pathogenesis of neurodegenerative diseases. Alpha-synuclein is a dynamic molecule whose secondary structure depends on the environment. For example, it has an unfolded random coil structure in aqueous solution, forms a-helical structure upon binding to acidic phospholipid vesicles, and forms insoluble fibrils with a high b-sheet content that resemble the filaments found in Lewy bodies. Also, alpha-synuclein was known to associate with 14-3-3 proteins including protein kinase C, BAD, and extracellular regulated kinase, and overexpression of alpha-synuclein could contribute to cell death in neurodegenerative diseases.
• Technical data
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  α-Synuclein/SNCA   Protein   N-6His   50µg  
• Gene symbol
  SNCA-AS1, SNCA
• Short name
  Recombinant Mouse α-Synuclein/SNCA Protein(N-6His) 50µg
• Technique
  Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Host
  mouse
• Species
  Mouse, Mouses
• Alternative name
  Rec. Mouse α-Synuclein/synuclein, alpha (non A4 component on amyloid precursor) Protein(N-6His) 50µg
• Alternative technique
  rec, murine
• Alternative to gene target
  synuclein, alpha (non A4 component of amyloid precursor), NACP and PARK1 and PARK4 and PD1, SNCA and IDBG-30077 and ENSG00000145335 and 6622, phosphoprotein binding, nuclei, Snca and IDBG-152558 and ENSMUSG00000025889 and 20617, SNCA and IDBG-641103 and ENSBTAG00000024957 and 282857

Gene info

• Identity
  HGNC:50600
• Gene
  SNCA-AS1
• Long gene name
  SNCA antisense RNA 1
• Locus
  4q22.1
• Discovery year
  2014-05-22
• Entrez gene record
  644248
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000161186

Gene info

• Identity
  HGNC:11138
• Gene
  SNCA
• Long gene name
  synuclein alpha
• Synonyms gene
  • PARK1
  • PARK4
• Synonyms gene name
  • Parkinson disease (autosomal dominant, Lewy body) 4
  • synuclein, alpha (non A4 component of amyloid precursor)
• Synonyms
  • NACP
  • PD1
• Synonyms name
  • non A4 component of amyloid precursor
  • alpha-synuclein
  • α-synuclein
• GenBank acession
  • L08850
• Locus
  4q22.1
• Discovery year
  1995-01-24
• Entrez gene record
  6622
• Pubmed identfication
  • 8248242
  • 14593171
• VEGA ID
  OTTHUMG00000130948
• Locus Specific Databases
  • Global Variome shared LOVD

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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