Recombinant Human TGM2 / Transglutaminase 2 Protein (His tag) 100µg

• Catalog number
  PKSH031259-100µg
• Price
  Please ask
• Size
  100µg

• Synonym
  G-ALPHA-h;GNAH;HEL-S-45;TG2;TGC
• Activity
  NA
• Sequence
  Met 1-Ala 687
• Fusion tag
  N-His
• Accession
  NP_004604.2
• Expressed Host
  Baculovirus-Insect Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞97 % as determined by SDS-PAGE
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  79.6 kDa
• AP Mol Mass
  80 kDa
• Formulation
  Lyophilized from sterile 50mM Tris, 100mM NaCl, 2mM DTT, 10% glycerol, pH 8.0
• Reconstitution
  Please refer to it for detailed information.
• Background
  Protein-glutamine gamma-glutamyltransferase 2, also known as Tissue transglutaminase, Transglutaminase C, Transglutaminase-2, and TGM2, is a member of the transglutaminase superfamily. TGM2 plays a role in cell growth and survival through the anti-apoptosis signaling pathway. It is a calcium-dependent acyltransferase which also undergoes a GTP-binding/GTPase cycle even though it lacks any obvious sequence similarity with canonical GTP-binding (G) proteins. TGM2 is a multi-functional protein which catalyzes transamidation reactions or acts as a G-protein in intracellular signalling. As an enzyme which is responsible for the majority of transglutaminase (TG) activity in the brain, TGM2 is likely to play a modulatory role in nervous system development and has regulatory effect on neuronal cell death as well. Most importantly, numerous studies have presented data demonstrating that dysregulation of TGM2 may contribute to the pathogenesis of many neurodegenerative disorders, including Huntington's disease, Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis as well as nervous system injuries.
• Product URL
• PDF URL
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  TGM2   Transglutaminase   Protein   His   tag   100µg  
• Gene symbol
  TGM2
• Short name
  Recombinant TGM2 / Transglutaminase 2 Protein (His tag) 100µg
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) / Transglutaminase 2 Protein (histidine detection labelled) 100µg
• Alternative technique
  rec
• Alternative to gene target
  transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase), G-ALPHA-h and GNAH and HEL-S-45 and TG2 and TGC, TGM2 and IDBG-74569 and ENSG00000198959 and 7052, metal ion binding, Plasma membranes, Tgm2 and IDBG-211417 and ENSMUSG00000037820 and 21817, TGM2 and IDBG-642580 and ENSBTAG00000016208 and 281528

Gene info

• Identity
  HGNC:11778
• Gene
  TGM2
• Long gene name
  transglutaminase 2
• Synonyms gene name
  • transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
• Synonyms
  • TGC
• Synonyms name
  • C polypeptide, protein-glutamine-gamma-glutamyltransferase
• GenBank acession
  • M98478
• Locus
  20q11.23
• Discovery year
  1991-08-02
• Entrez gene record
  7052
• Pubmed identfication
  • 7912692
  • 11390390
• RefSeq identity
  • NM_198951
• Classification
  • Transglutaminases
• VEGA ID
  OTTHUMG00000032437

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

Similar products