Recombinant Human SNCA / alpha-Synuclein Protein 200µg

• Catalog number
  PKSH030906-200µg
• Price
  Please ask
• Size
  200µg

• Synonym
  NACP;PARK1;PARK4;PD1
• Activity
  NA
• Sequence
  Met 1-Ala 140
• Fusion tag
  NA
• Accession
  P37840-1
• Expressed Host
  E. coli
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞97 % as determined by SDS-PAGE
• Endotoxin
  Please contact us for more information.
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  14.5 kDa
• AP Mol Mass
  19 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Reconstitution
  Please refer to it for detailed information.
• Background
  Alpha-Synuclein (alpha-Syn), also known as NACP or SNCA, exists as at least two structural isoforms: one is helix-rich, membrane-bound form that both the N- and C-terminal regions of alpha-synuclein are tightly associated with membranes and the other is disordered, cytosolic form. Synuclein is found predominantly in the presynaptic termini, in both free or membrane-bound forms. SNCA is extensively localized in nucleus of neurons. It has been shown that alpha-Synuclein was highly expressed in the mitochondria in olfactory bulb, hippocampus, striatum, and thalamus, where the cytosolic alpha-Synuclein was also rich. Normally the unstructured soluble type of alpha-synuclein can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. SNCA abnormality and mitochondrial deficiency are two major changes in the brain of patients with Parkinson's disease (PD). In addition, alpha-synuclein is an abundant component of Lewy bodies in sporadic Parkinson's disease and diffuse Lewy body disease.
• Product URL
• PDF URL
• Description
  The Recombinant SNCA / alpha-Synuclein Protein 200µg is a α- or alpha protein sometimes glycoprotein present in blood.
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  SNCA   alpha-Synuclein   Protein   200µg  
• Gene symbol
  SNCA-AS1, SNCA
• Short name
  Recombinant SNCA / alpha-Synuclein Protein 200µg
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens synuclein, alpha (non A4 component on amyloid precursor) / a-Synuclein Protein 200µg
• Alternative technique
  rec
• Alternative to gene target
  synuclein, alpha (non A4 component of amyloid precursor), NACP and PARK1 and PARK4 and PD1, SNCA and IDBG-30077 and ENSG00000145335 and 6622, phosphoprotein binding, nuclei, Snca and IDBG-152558 and ENSMUSG00000025889 and 20617, SNCA and IDBG-641103 and ENSBTAG00000024957 and 282857

Gene info

• Identity
  HGNC:50600
• Gene
  SNCA-AS1
• Long gene name
  SNCA antisense RNA 1
• Locus
  4q22.1
• Discovery year
  2014-05-22
• Entrez gene record
  644248
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000161186

Gene info

• Identity
  HGNC:11138
• Gene
  SNCA
• Long gene name
  synuclein alpha
• Synonyms gene
  • PARK1
  • PARK4
• Synonyms gene name
  • Parkinson disease (autosomal dominant, Lewy body) 4
  • synuclein, alpha (non A4 component of amyloid precursor)
• Synonyms
  • NACP
  • PD1
• Synonyms name
  • non A4 component of amyloid precursor
  • alpha-synuclein
  • α-synuclein
• GenBank acession
  • L08850
• Locus
  4q22.1
• Discovery year
  1995-01-24
• Entrez gene record
  6622
• Pubmed identfication
  • 8248242
  • 14593171
• VEGA ID
  OTTHUMG00000130948
• Locus Specific Databases
  • Global Variome shared LOVD

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

Similar products