Recombinant Human SETD8 / PR-Set7 Protein

• Catalog number
  PKSH031024-50µg
• Price
  Please ask
• Size
  50µg

• Synonym
  KMT5A;PR-Set7;SET07;SET8
• Activity
  NA
• Sequence
  Lys 195-His 352
• Fusion tag
  NA
• Accession
  NP_065115.3
• Expressed Host
  E. coli
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  > 98 % as determined by SDS-PAGE
• Endotoxin
  Please contact us for more information.
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  18.2 kDa
• AP Mol Mass
  18 kDa
• Formulation
  Lyophilized from sterile 20mM Tris, 100mM NaCl, pH 8.0
• Background
  Ubiquitin carboxyl-terminal hydrolase 7, also known as Ubiquitin thioesterase 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin-specific-processing protease 7, USP7 and HAUSP, is a widely expressed protein which belongs to the peptidase C19 family. USP7 is a member of the family of deubiquitinating enzymes. It is involved in the regulation of stress response pathways, epigenetic silencing and the progress of infections by DNA viruses. USP7 is a protein with a cysteine peptidase core, N- and C-terminal domains required for protein-protein interactions. USP7 contributes to epigenetic silencing of homeotic genes by Polycomb (Pc). USP7 cleaves ubiquitin fusion protein substrates. It deubiquitinates TP53/p53 and MDM2 and strongly stabilizes TP53 even in the presence of excess MDM2. USP7 also induces TP53-dependent cell growth repression and apoptosis. USP7 has key roles in the p53 pathway whereby it stabilizes both p53 and MDM2. Herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 stimulates lytic infection and the reactivation of quiescent viral genomes. ICP0 interacts very strongly with USP7. USP7-mediated stabilization of ICP0 is dominant over ICP0-induced degradation of USP7 during productive HSV-1 infection. The biological significance of the ICP0-USP7 interaction may be most pronounced in natural infection situations, in which limited amounts of ICP0 are expressed.
• Technical data
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  SETD8   PR-Set7   Protein  
• Gene symbol
  KMT5A, PRH2, TMEM37, PGR, PRTN3
• Short name
  Recombinant SETD8 / PR-Set7 Protein
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens SETD8 / PR-Set7 Protein
• Alternative technique
  rec

Gene info

• Identity
  HGNC:29489
• Gene
  KMT5A
• Long gene name
  lysine methyltransferase 5A
• Synonyms gene
  • SETD8
• Synonyms gene name
  • SET domain containing (lysine methyltransferase) 8
  • lysine (K)-specific methyltransferase 5A
• Synonyms
  • SET8
  • SET07
  • PR-Set7
• GenBank acession
  • AY102937
• Locus
  12q24.31
• Discovery year
  2006-02-15
• Entrez gene record
  387893
• Pubmed identfication
  • 15933070
  • 12086618
  • 12121615
• RefSeq identity
  • NM_020382
• Classification
  • SET domain containing
  • Lysine methyltransferases
• VEGA ID
  OTTHUMG00000150477

Gene info

• Identity
  HGNC:9367
• Gene
  PRH2
• Long gene name
  proline rich protein HaeIII subfamily 2
• Synonyms
  • Pr
• Synonyms name
  • parotid proline-rich protein
  • acidic salivary proline-rich protein, HaeIII type, 2
• Locus
  12p13.2
• Discovery year
  2001-06-22
• Entrez gene record
  5555
• Pubmed identfication
  • 3009472
• RefSeq identity
  • NM_001110213
• Classification
  • Proline rich proteins
• VEGA ID
  OTTHUMG00000168556

Gene info

• Identity
  HGNC:18216
• Gene
  TMEM37
• Long gene name
  transmembrane protein 37
• Synonyms
  • PR1
  • PR
• GenBank acession
  • AF361356
• Locus
  2q14.2
• Discovery year
  2004-12-14
• Entrez gene record
  140738
• RefSeq identity
  • NM_183240
• VEGA ID
  OTTHUMG00000153304

Gene info

• Identity
  HGNC:8910
• Gene
  PGR
• Long gene name
  progesterone receptor
• Synonyms
  • PR
  • NR3C3
• GenBank acession
  • M15716
• Locus
  11q22.1
• Discovery year
  2001-06-22
• Entrez gene record
  5241
• RefSeq identity
  • NM_000926
• Classification
  • Nuclear receptor subfamily 3 group C
• VEGA ID
  OTTHUMG00000167531

Gene info

• Identity
  HGNC:9495
• Gene
  PRTN3
• Long gene name
  proteinase 3
• Synonyms
  • PR-3
  • ACPA
  • C-ANCA
  • AGP7
  • MBT
  • P29
• Synonyms name
  • myeloblastin
  • serine proteinase, neutrophil
  • Wegener granulomatosis autoantigen
• Locus
  19p13.3
• Discovery year
  1992-08-24
• Entrez gene record
  5657
• Pubmed identfication
  • 2258701
• RefSeq identity
  • NM_002777
• Classification
  • Granule associated serine proteases of immune defence
• VEGA ID
  OTTHUMG00000181838

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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