Recombinant Human Semaphorin 5A / SEMA5A Protein (Fc tag) 50µg

• Catalog number
  PKSH031162-50µg
• Price
  Please ask
• Size
  50µg

• Synonym
  SEMAF;semF
• Activity
  NA
• Sequence
  Met 1-Thr 765
• Fusion tag
  C-Fc
• Accession
  NP_003957.2
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞90 % as determined by SDS-PAGE
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  110.7 kDa
• AP Mol Mass
  125-135 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Reconstitution
  Please refer to it for detailed information.
• Background
  Semaphorins are secreted, transmembrane, and GPI-linked proteins, defined by cysteine-rich semaphorin protein domains, that have important roles in a variety of tissues. Humans have 20 semaphorins, Drosophila has five, and two are known from DNA viruses. Semaphorins are found in nematodes and crustaceans but not in non-animals. They are grouped into eight classes on the basis of phylogenetic tree analyses and the presence of additional protein motifs. Semaphorins have been implicated in diverse developmental processes such as axon guidance during nervous system development and regulation of cell migration. Semaphorin-5A, also known as Semaphorin-F, Sema F, SEMA5A and SEMAF, is a single-pass type I membrane protein which belongs to the semaphorin family. Semaphorin5A / SEMA5A contains one PSI domain, one Sema domain and seven TSP type-1 domains. It may act as positive axonal guidance cues. Semaphorin5A / SEMA5A is an axon regulator molecule and plays major roles during neuronal and vascular development. It plays an essential role in embryonic development. Semaphorin5A / SEMA5A induces endothelial cell migration from pre-existing vessels. It also plays a role in autism, reducing the ability of neurons to form connections with other neurons in certain brain regions.
• Product URL
• PDF URL
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Semaphorin   SEMA5A   Protein   tag   50µg  
• Gene symbol
  SEMA5A-AS1, SEMA5A
• Short name
  Recombinant Semaphorin 5A / SEMA5A Protein (Fc tag) 50µg
• Technique
  Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  Fc Tag
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens Semaphorin 5A / sema domain, seven thrombospondin repeats (classification 1 and classification 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A Protein (fragment c detection labelled) 50µg
• Alternative technique
  rec
• Alternative to gene target
  sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A, SEMAF and semF, SEMA5A and IDBG-12173 and ENSG00000112902 and 9037, syndecan binding, Plasma membranes, Sema5a and IDBG-133049 and ENSMUSG00000022231 and 20356, SEMA5A and IDBG-631754 and ENSBTAG00000005021 and 506636

Gene info

• Identity
  HGNC:52973
• Gene
  SEMA5A-AS1
• Long gene name
  SEMA5A antisense RNA 1
• Locus
  5p15.31
• Discovery year
  2016-12-22
• Entrez gene record
  101929338
• RefSeq identity
  • NR_109935
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000161718

Gene info

• Identity
  HGNC:10736
• Gene
  SEMA5A
• Long gene name
  semaphorin 5A
• Synonyms gene
  • SEMAF
• Synonyms gene name
  • sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
• Synonyms
  • semF
• GenBank acession
  • U52840
• Locus
  5p15.31
• Discovery year
  1999-06-25
• Entrez gene record
  9037
• Pubmed identfication
  • 8817451
  • 9464278
• Classification
  • MicroRNA protein coding host genes
  • Semaphorins
• VEGA ID
  OTTHUMG00000090501

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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