Recombinant Human S100A10 Protein (His tag)

• Catalog number
  PKSH031240-50µg
• Price
  Please ask
• Size
  50µg

• Synonym
  42C;ANX2L;ANX2LG;CAL1L;Ca[1];CLP11;GP11;MGC111133;p10;P11
• Activity
  NA
• Sequence
  Pro 2-Lys 97
• Fusion tag
  N-His
• Accession
  NP_002957.1
• Expressed Host
  E. coli
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞95 % as determined by SDS-PAGE
• Endotoxin
  Please contact us for more information.
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  12.6 kDa
• AP Mol Mass
  12.6 kDa
• Formulation
  Lyophilized from sterile 20mM Tris, pH 8.5, 10% glycerol
• Background
  S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of intracellular and extracellular functions. They are involved in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response.   Protein S100-A10, also known as Calpactin I light chain, Cellular ligand of annexin II, S100 calcium-binding protein A10, p10 protein, p11, ANX2LG and S100A10, is a member of the S100 family of small, dimeric EF hand-type Ca(2+)-binding proteins that generally modulate cellular target proteins in response to intracellular Ca(2+) signals. In contrast to all other S100 proteins, S100A10 is Ca(2+) insensitive because of amino acid replacements in its Ca(2+)-binding loops that lock the protein in a permanently active state. S100A10 forms a heterotetramer with annexin IIH and promotes carcinoma invasion and metastasis by plasminogen activation. S100A10 and annexin II contribute to the aggressive characteristics of anaplastic carcinoma, while playing a constitutive role in papillary carcinoma. S100A10 induces the dimerization of ANXA2 / p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target of tyrosine-specific kinase. S100A10 functions as a linker tethering certain transmembrane proteins to annexin A2 thereby assisting their traffic to the plasma membrane and/or their firm anchorage at certain membrane sites.
• Technical data
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  S100A10   Protein   His   tag  
• Gene symbol
  S100A10
• Short name
  Recombinant S100A10 Protein (His tag)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens S100A10 Protein (histidine detection labelled)
• Alternative technique
  rec

Gene info

• Identity
  HGNC:10487
• Gene
  S100A10
• Long gene name
  S100 calcium binding protein A10
• Synonyms gene
  • ANX2LG
  • CAL1L
• Synonyms gene name
  • S100 calcium-binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11))
• Synonyms
  • P11
  • 42C
  • CLP11
• Synonyms name
  • annexin II tetramer (AIIt) p11 subunit
  • calpactin I
• GenBank acession
  • BC015973
• Locus
  1q21.3
• Discovery year
  1992-09-10
• Entrez gene record
  6281
• Pubmed identfication
  • 8276421
• RefSeq identity
  • NM_002966
• Classification
  • S100 calcium binding proteins
• VEGA ID
  OTTHUMG00000013068

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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