Recombinant Human Prealbumin / Transthyretin / TTR / PALB Protein (His tag)

• Catalog number
  PKSH030907-50µg
• Price
  Please ask
• Size
  50µg

• Synonym
  CTS;CTS1;HEL111;HsT2651;PALB;TBPA
• Activity
  Measured by its binding ability in a functional ELISA.Immobilized recombinant human TTR-His at 10 μg/ml (100 μl/well) can bind recombinant Canine RBP4-Fc with a linear range of 0.3-10.0 μg/ml.
• Sequence
  Met 1-Glu 147
• Fusion tag
  C-His
• Accession
  NP_000362.1
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞97 % as determined by SDS-PAGE
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  15.2 kDa
• AP Mol Mass
  15.2 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  Prealbumin/Transthyretin, also known as ATTR, Prealbumin, TTR and PALB, is a secreted and cytoplasm protein which belongs to the Prealbumin / Transthyretin family. Prealbumin / Transthyretin is detected in serum and cerebrospinal fluid (at protein level). It is highly expressed in choroid plexus epithelial cells. It is also detected in retina pigment epithelium and liver. Each monomer of Prealbumin / Transthyretin has two 4-stranded beta sheets and the shape of a prolate ellipsoid. Antiparallel beta-sheet interactions link monomers into dimers. A short loop from each monomer forms the main dimer-dimer interaction. These two pairs of loops separate the opposed, convex beta-sheets of the dimers to form an internal channel. Prealbumin/Transthyretin is a carrier protein. It transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. Defects in Prealbumin / Transthyretin are the cause of amyloidosis type 1 (AMYL1) which is a hereditary generalized amyloidosis due to Prealbumin / Transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.
• Technical data
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Prealbumin   Transthyretin   TTR   PALB   Protein   His   tag  
• Gene symbol
  TTR
• Short name
  Recombinant Prealbumin / Transthyretin / TTR / PALB Protein (His tag)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens Prealbumin / Transthyretin / TTR / PALB Protein (histidine detection labelled)
• Alternative technique
  rec

Gene info

• Identity
  HGNC:12405
• Gene
  TTR
• Long gene name
  transthyretin
• Synonyms gene
  • PALB
  • CTS1
• Synonyms gene name
  • prealbumin, amyloidosis type I
  • carpal tunnel syndrome 1
• Synonyms
  • HsT2651
  • CTS
• GenBank acession
  • M10605
• Locus
  18q12.1
• Discovery year
  1986-01-01
• Entrez gene record
  7276
• Pubmed identfication
  • 8309582
  • 11385707
• RefSeq identity
  • NM_000371
• Classification
  • Gla domain containing
• VEGA ID
  OTTHUMG00000131984
• Locus Specific Databases
  • LSDB list
  • LRG_416

MeSH Data

• Name
  Real-Time Polymerase Chain Reaction
• Concept
  Scope note: Methods used for detecting the amplified DNA products from the polymerase chain reaction as they accumulate instead of at the end of the reaction.
• Tree numbers
  • E05.393.620.500.706
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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