Recombinant Human Phosphomannomutase 2/PMM2 Protein(C-6His)

• Catalog number
  PKSH032894-10µg
• Price
  Please ask
• Size
  10µg

• Synonym
  Phosphomannomutase 2; PMM 2; PMM2
• Activity
  NA
• Sequence
  Met1-Ser246
• Fusion tag
  C-6His
• Accession
  O15305
• Expressed Host
  E.coli
• Shipping
  The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
• Purity
  ＞95% as determined by reducing SDS-PAGE.
• Endotoxin
  ＜1.0 EU per µg as determined by LAL test.
• Stability and Storage
  Store at < -20℃, stable for 6 monthshs after receipt.Please minimize freeze-thaw cycles
• Mol Mass
  29.1 kDa
• AP Mol Mass
  29 kDa
• Formulation
  Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.
• Background
  Phosphomannomutase 2 (PMM2) is an enzyme that is a member of the highly variable methyltransferase superfamily. PMM2 is a cytoplasmic protein and catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate.In addition, PMM2 involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose that required for a number of critical mannosyl transfer reactions. Defects in PMM2 can results in congenital disorder of glycosylation type 1A (CDG1A). Congenital disorders of glycosylation are metabolic deficiencies in glycoprotein biosynthesis that usually cause severe mental and psychomotor retardation.
• Technical data
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Phosphomannomutase   2/PMM2   Protein   C-6His  
• Gene symbol
  PMM2
• Short name
  Recombinant Phosphomannomutase 2/PMM2 Protein(C-6His)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens Phosphomannomutase 2/PMM2 Protein(C-6His)
• Alternative technique
  rec

Gene info

• Identity
  HGNC:9115
• Gene
  PMM2
• Long gene name
  phosphomannomutase 2
• Synonyms gene
  • CDG1
• Synonyms
  • CDGS
  • CDG1a
  • PMI
  • PMI1
• Synonyms name
  • phosphomannose isomerase 1
  • mannose-6-phosphate isomerase
  • Congenital disorder of glycosylation, type Ia
• GenBank acession
  • BC008310
• Locus
  16p13.2
• Discovery year
  1997-05-22
• Entrez gene record
  5373
• Pubmed identfication
  • 9140401
• RefSeq identity
  • NM_000303
• Classification
  • HAD Asp-based non-protein phosphatases
• VEGA ID
  OTTHUMG00000129697
• Locus Specific Databases
  • Congenital Disorders of Glycosylation pages

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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