Recombinant Human NPM1 / Nucleophosmin Protein (His tag) 100µg

• Catalog number
  PKSH031911-100µg
• Price
  Please ask
• Size
  100µg

• Synonym
  B23;NPM
• Activity
  NA
• Sequence
  Met 9-Leu 158
• Fusion tag
  N-His
• Accession
  P06748-1
• Expressed Host
  E. coli
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞90 % as determined by SDS-PAGE
• Endotoxin
  Please contact us for more information.
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  17.8 kDa
• AP Mol Mass
  20 kDa
• Formulation
  Lyophilized from sterile PBS, pH 6.0
• Reconstitution
  Please refer to it for detailed information.
• Background
  Nucleophosmin 1 (NPM1), also known as nucleolar phosphoprotein B23 or numatrin, is a member of the nucleoplasmin family. Nucleophosmin (NPM) is a nucleolar phosphoprotein that plays multiple roles in ribosome assembly and transport, cytoplasmic-nuclear trafficking, centrosome duplication and regulation of p53. The NPM1 gene is frequently involved in chromosomal translocation, mutation and deletion. Mutations of the NPM1 gene leading to the expression of a cytoplasmic mutant protein, NPMc+, are the most frequent genetic abnormalities found in acute myeloid leukemias. Acute myeloid leukemias (AML) with mutated NPM1 have distinct characteristics, including a significant association with a normal karyotype, involvement of different hematopoietic lineages, a specific gene-expression profile and clinically, a better response to induction therapy and a favorable prognosis. In addition, NPM1 is a crucial gene to consider in the context of the genetics and biology of cancer. NPM1 is frequently overexpressed, mutated, rearranged and deleted in human cancer. Traditionally regarded as a tumour marker and a putative proto-oncogene, it has now also been attributed with tumour-suppressor functions.
• Product URL
• PDF URL
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  NPM1   Nucleophosmin   Protein   His   tag   100µg  
• Gene symbol
  NPM1
• Short name
  Recombinant NPM1 / Nucleophosmin Protein (His tag) 100µg
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens nucleophosmin (nucleolar phosphoprotein B23, numatrin) / Nucleophosmin Protein (histidine detection labelled) 100µg
• Alternative technique
  rec
• Alternative to gene target
  nucleophosmin (nucleolar phosphoprotein B23, numatrin), B23 and NPM, NPM1 and IDBG-57453 and ENSG00000181163 and 4869, unfolded protein binding, nuclei

Gene info

• Identity
  HGNC:7910
• Gene
  NPM1
• Long gene name
  nucleophosmin 1
• Synonyms gene name
  • nucleophosmin (nucleolar phosphoprotein B23, numatrin)
  • nucleophosmin
• Synonyms
  • B23
  • NPM
• Synonyms name
  • nucleolar phosphoprotein B23
  • numatrin
  • nucleophosmin/nucleoplasmin family, member 1
• GenBank acession
  • M26697
• Locus
  5q35.1
• Discovery year
  1993-08-24
• Entrez gene record
  4869
• Pubmed identfication
  • 8471164
  • 8122112
• RefSeq identity
  • NM_002520
• VEGA ID
  OTTHUMG00000130465
• Locus Specific Databases
  • LRG_458

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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