Recombinant Human MBL2 / MBL / COLEC1 Protein

• Catalog number
  PKSH031629-50µg
• Price
  Please ask
• Size
  50µg

• Synonym
  COLEC1;HSMBPC;MBL;MBL2D;MBP;MBP-C;MBP1;MBPD
• Activity
  NA
• Sequence
  Met1-Ile 248
• Fusion tag
  NA
• Accession
  NP_000233.1
• Expressed Host
  CHO Stable Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞95 % as determined by SDS-PAGE
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  24 kDa
• AP Mol Mass
  31 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein, which binds sugar structures on micro-organisms and on dying host cells and is one of the four known mediators that initiate activation of the complement system via the lectin pathway. MBL and the ficolins (Ficolin-1, Ficolin-2 and Ficolin-3) are soluble collagen-like proteins that are involved in innate immune defence. They bind sugar structures or acetylated compounds present on microorganisms and on dying host cells and they initiate activation of the lectin complement pathway in varying degrees. MBL2 encodes the mannose-binding lectin, which is a key player in the innate immune system and has recently been found to play a role in development of type 1 diabetes and gestational diabetes mellitus. Common variant alleles situated both in promoter and structural regions of the MBL2 gene influence the stability and the serum concentration of the protein. Several polymorphisms in the promoter and structural regions of MBL2 adversely affect the plasma concentration and oligomeric state of MBL. The possession of mutant alleles has been linked to disease outcome for a variety of bacterial and viral infections. Mutant MBL2 haplotypes have been linked to disease progression and response to therapy in HCV infection.
• Technical data
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  MBL2   MBL   COLEC1   Protein  
• Gene symbol
  MBL2, LNCAROD
• Short name
  Recombinant MBL2 / MBL / COLEC1 Protein
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens mannose-binding lectin (protein C) 2, soluble / MBL / COLEC1 Protein
• Alternative technique
  rec
• Alternative to gene target
  mannose-binding lectin (protein C) 2, soluble, COLEC1 and HSMBPC and MBL and MBL2D and MBP and MBP-C and MBP1 and MBPD, MBL2 and IDBG-74690 and ENSG00000165471 and 4153, calcium-dependent protein binding, Extracellular, Mbl2 and IDBG-158106 and ENSMUSG00000024863 and 17195, MBL and IDBG-637084 and ENSBTAG00000007049 and 281297

Gene info

• Identity
  HGNC:6922
• Gene
  MBL2
• Long gene name
  mannose binding lectin 2
• Synonyms gene
  • MBL
• Synonyms gene name
  • mannose-binding lectin (protein C) 2, soluble (opsonic defect)
  • mannose-binding lectin (protein C) 2, soluble
• Synonyms
  • COLEC1
• GenBank acession
  • AF360991
• Locus
  10q21.1
• Discovery year
  1990-05-25
• Entrez gene record
  4153
• Pubmed identfication
  • 1675710
  • 1672848
• RefSeq identity
  • NM_000242
• Classification
  • Complement system activation components
  • Collectins
• VEGA ID
  OTTHUMG00000150270
• Locus Specific Databases
  • LRG_154

Gene info

• Identity
  HGNC:50913
• Gene
  LNCAROD
• Long gene name
  lncRNA activating regulator of DKK1
• Synonyms gene
  • LINC01468
• Synonyms gene name
  • long intergenic non-protein coding RNA 1468
• Synonyms
  • lnc-MBL2-4
  • A-ROD
• Synonyms name
  • Activating Regulator of DKK1
• Locus
  10q21.1
• Discovery year
  2014-07-28
• Entrez gene record
  101928687
• Pubmed identfication
  • 25045670
  • 29691407
• RefSeq identity
  • NR_120641
• Classification
  • Long non-coding RNAs with non-systematic symbols
• VEGA ID
  OTTHUMG00000018252

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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