Recombinant Human Major Prion Protein/PRP/CD230 Protein 50µg

• Catalog number
  PKSH032729-50µg
• Price
  Please ask
• Size
  50µg

• Synonym
  Major Prion Protein; PrP; ASCR; PrP27-30; PrP33-35C; CD230; PRNP; PRIP; PRP
• Activity
  NA
• Sequence
  Gln91-Ser231
• Fusion tag
  NA
• Accession
  P04156
• Expressed Host
  E.coli
• Shipping
  The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
• Purity
  ＞90% as determined by reducing SDS-PAGE.
• Endotoxin
  ＜1.0 EU per µg as determined by LAL test.
• Stability and Storage
  Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
• Mol Mass
  16.3 kDa
• AP Mol Mass
  15 kDa
• Formulation
  Lyophilized from a 0.2 μm filtered solution of 5mM PB, 200mM NaCl, pH 7.5.
• Reconstitution
  Please refer to it for detailed information.
• Background
  Major Prion Protein is unique in its ability to reproduce on its own and become infectious. The discovery of prion proteins as infectious agents began in the 1980s with an outbreak of mad cow disease in the United Kingdom. They are found in high quantity in the brain of humans and animals infected with neurodegenerative diseases known as transmissible spongiform encephalopathies or prion diseases. They can occur in two forms called PrP-sen and PrP-res. The normal, monomeric form has a mainly alpha-helical structure. The disease-associated, protease-resistant form forms amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Disease mutations may favor intermolecular contacts via short beta strands, and may thereby trigger oligomerization. Contains an N-terminal region composed of octamer repeats. Diseases caused by prions are known as spongiform diseases, because the brain tissue in infected individuals is filled with holes, giving it a sponge-like appearance. Although prions are found throughout the brain, the symptoms of spongiform diseases vary according to the regions. There are currently no effective treatments for spongiform diseases and all are fatal. Prions cannot be destroyed by boiling, alcohol, acid, standard autoclaving methods, or radiation. In fact, infected brains that have been sitting in formaldehyde for decades can still transmit spongiform disease.
• Product URL
• PDF URL
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Major   Prion   Protein/PRP/CD230   Protein   50µg  
• Gene symbol
  PRNP, PLGLB1, PRDX2
• Short name
  Recombinant Major Prion Protein/PRP/CD230 Protein 50µg
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens Major Prion Protein/PRP/CD230 Protein 50µg
• Alternative technique
  rec

Gene info

• Identity
  HGNC:9449
• Gene
  PRNP
• Long gene name
  prion protein
• Synonyms gene
  • PRIP
  • GSS
  • CJD
• Synonyms gene name
  • prion protein (p27-30)
• Synonyms
  • CD230
  • PRP
  • AltPrP
• Synonyms name
  • Creutzfeldt-Jakob disease
  • Gerstmann-Strausler-Scheinker syndrome
  • fatal familial insomnia
  • p27-30
• GenBank acession
  • M13899
• Locus
  20p13
• Discovery year
  1986-01-01
• Entrez gene record
  5621
• RefSeq identity
  • NM_000311
• Classification
  • CD molecules
• VEGA ID
  OTTHUMG00000031786
• Locus Specific Databases
  • Prion Protein/CJD database

Gene info

• Identity
  HGNC:9072
• Gene
  PLGLB1
• Long gene name
  plasminogen like B1
• Synonyms gene
  • PLGL
• Synonyms gene name
  • plasminogen-like
• Synonyms
  • PRP-B
• GenBank acession
  • M86874
  • M86875
  • M86876
• Locus
  2p11.2
• Discovery year
  1989-05-10
• Entrez gene record
  5343
• Pubmed identfication
  • 1554698
  • 2714803
• VEGA ID
  OTTHUMG00000154612

Gene info

• Identity
  HGNC:9353
• Gene
  PRDX2
• Long gene name
  peroxiredoxin 2
• Synonyms gene
  • TDPX1
• Synonyms
  • PRP
  • NKEFB
  • TSA
  • PRXII
  • PRX2
  • MGC4104
• Synonyms name
  • thioredoxin-dependent peroxide reductase 1
  • thiol-specific antioxidant 1
  • natural killer-enhancing factor B
  • thioredoxin peroxidase 1
  • torin
• Locus
  19p13.13
• Discovery year
  1995-07-06
• Entrez gene record
  7001
• Pubmed identfication
  • 7607688
• RefSeq identity
  • NM_005809
• Classification
  • Peroxiredoxins
• VEGA ID
  OTTHUMG00000134285

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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