Recombinant Human IL17RA / CD217 Protein (His & Fc tag) 200µg
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Catalog number
PKSH031369-200µg
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Price
Please ask
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Size
200µg
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Synonym
CANDF5;CD217;CDw217;hIL-17R;IL-17RA;IL17R
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Activity
Measured by its ability to bind human IL17F in a functional ELISA.2. Measured by its binding ability in a functional ELISA.3. Immobilized recombinant human IL17A at 20 μg/ml (100 μl/well) can bind human IL17RA with a linear range of 32-160 ng/ml.
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Sequence
Met 1-Trp 320
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Fusion tag
C-His & Fc
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Accession
NP_055154.3
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Expressed Host
HEK293 Cells
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Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
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Purity
＞85 % as determined by SDS-PAGE
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Endotoxin
＜1.0 EU per µg as determined by the LAL method
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Stability and Storage
Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Mol Mass
61.5 kDa
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AP Mol Mass
95-105 kDa
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Formulation
Lyophilized from sterile PBS, pH 7.4
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Reconstitution
Please refer to it for detailed information.
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Background
Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor which binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
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Conjugation
histidine
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
IL17RA
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Short name
Recombinant IL17RA / CD217 Protein (His & Fc tag) 200µg
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Technique
Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
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Label
His
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Species
Human, Humans
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Alternative name
Rec. H. sapiens interleukin 17 receptor A / CD217 Protein (histidine & fragment c detection labelled) 200µg
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Alternative technique
rec
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Alternative to gene target
interleukin 17 receptor A, CANDF5 and CD217 and CDw217 and hIL-17R and IL-17RA and IL17R, IL17RA and IDBG-885 and ENSG00000177663 and 23765, interleukin-17 receptor activity, Extracellular, Il17ra and IDBG-183749 and ENSMUSG00000002897 and 16172, IL17RA and IDBG-641259 and ENSBTAG00000011067 and 525040
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Gene info
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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