Recombinant Human FKBP12 Protein (His tag) 200µg

• Catalog number
  PKSH031719-200µg
• Price
  Please ask
• Size
  200µg

• Synonym
  FKBP-12;FKBP-1A;FKBP1;FKBP12;PKC12;PKCI2;PPIASE
• Activity
  NA
• Sequence
  Met 1-Glu 108
• Fusion tag
  C-His
• Accession
  NP_463460
• Expressed Host
  E. coli
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞96 % as determined by SDS-PAGE
• Endotoxin
  Please contact us for more information.
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  12.9 kDa
• AP Mol Mass
  12.9 kDa
• Formulation
  Lyophilized from sterile PBS, 10% glycerol, pH 7.4
• Reconstitution
  Please refer to it for detailed information.
• Background
  FK506 binding protein 12 (FKBP12), also known as FKBP1, along with cyclophilin, are two major members of the immunophilin protein family who serve as receptors for the immunosuppressant drugs cyclosporin A and FK506. As a conserved molecules in many eukaryotes, FKBP12 has been characterized as a peptidyl-prolyl isomerase that catalyzes the transition between cis- and trans-proline residues, and is involved in several biochemical processes including protein folding, receptor signaling, protein trafficking and transcription. FKBP12 has attracted immense attention and its role in mediating the immunosuppressive functions. FKBP12 serves a dual role as a peptidyl-prolyl cis-trans isomerase and as a modulator of several cell signaling pathways. In one such a role, FKBP12 interacts with and regulates the functional state of the ryanodine Ca2+ channel receptor by altering protein conformation and coordinating multi-protein complex formation. Another physiological role of FKBP12 is an interactor and a regulator of the type I serine/threonine kinase receptors of TGF-beta superfamily. Current data, derived from detailed biochemical studies as well as from functional studies in various systems, suggest that FKBP12 functions as a "guardian" for the type I receptors to prevent them from leaky signaling under sub-optimal ligand concentrations, thereby providing a molecular "gradient reader" for TGF-beta family morphogens. This aspect of FKBP12 function may be critical for cellular responsiveness to morphogenetic gradients of the TGF-beta family members during early development, serving to assure the translation of different ligand concentrations into different signaling readouts. In addition, FKBP12 may be involved in neuronal or astrocytic cytoskeletal organization and in the abnormal metabolism of tau protein in Alzheimer's disease (AD) damaged neurons.
• Product URL
• PDF URL
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  FKBP12   Protein   His   tag   200µg  
• Gene symbol
  FKBP1A
• Short name
  Recombinant FKBP12 Protein (His tag) 200µg
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens FKBP12 Protein (histidine detection labelled) 200µg
• Alternative technique
  rec

Gene info

• Identity
  HGNC:3711
• Gene
  FKBP1A
• Long gene name
  FKBP prolyl isomerase 1A
• Synonyms gene
  • FKBP1
• Synonyms gene name
  • FK506-binding protein 1A (12kD)
  • FK506 binding protein 1A, 12kDa
  • FK506 binding protein 1A
• Synonyms
  • FKBP-12
  • FKBP12
  • PKC12
  • PPIASE
  • FKBP12C
• Synonyms name
  • calstabin 1
• GenBank acession
  • M92423
• Locus
  20p13
• Discovery year
  1992-09-14
• Entrez gene record
  2280
• Pubmed identfication
  • 1930186
• Classification
  • FKBP prolyl isomerases
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000031666

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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