Recombinant Human Fibronectin Leucine Rich Transmembrane Protein 2 Protein

• Catalog number
  PKSH031164-10µg
• Price
  Please ask
• Size
  10µg

• Synonym
  Leucine-Rich Repeat Transmembrane Protein FLRT2; Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 2; FLRT2; KIAA0405
• Activity
  Measured by the ability of the immobilized protein to support the adhesion of Neuro‑2A mouse neuroblastoma cells.When cells are added to coated plates(5μg/mL, 100μL/well), approximately 50%-70% will adhere after 1 hour at 37℃.
• Sequence
  Cys36-Ser539
• Fusion tag
  C-6His
• Accession
  O43155
• Expressed Host
  Human cells
• Shipping
  The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
• Purity
  ＞95% as determined by reducing SDS-PAGE.
• Endotoxin
  ＜1.0 EU per µg as determined by LAL test.
• Stability and Storage
  Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
• Mol Mass
  57.3 kDa
• AP Mol Mass
  78 kDa
• Formulation
  Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
• Background
  Fibronectin Leucine Rich Transmembrane protein 2 (FLRT2) is a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The three fibronectin leucine-rich repeat transmembrane (FLRT) proteins: FLRT1, FLRT2 and FLRT3, all contain 10 leucine-rich repeats (LRR), a type III fibronectin (FN) domain, followed by the transmembrane region, and a short cytoplasmic tail. FLRT proteins have dual properties as regulators of cell adhesion and potentiators of fibroblast growth factor (FGF) mediated signalling. The fibronectin domain of all three FLRTs can bind FGF receptors. This binding is thought to regulate FGF signaling during development. The LRR domains are responsible for both the localization of FLRTs in areas of cell contact and homotypic cell cell association. FLRT2 is expressed in a subset of the sclerotome, adjacent to the region that forms the syndetome, suggesting its involvement in the FGF signalling pathway.
• Technical data
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Fibronectin   Leucine   Rich   Transmembrane   Protein   Protein  
• Gene symbol
  FLRT2
• Short name
  Recombinant Fibronectin Leucine Rich Transmembrane Protein 2 Protein
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens Fibronectin Leucine Rich Transmembrane Protein 2 Protein
• Alternative technique
  rec

Gene info

• Identity
  HGNC:3761
• Gene
  FLRT2
• Long gene name
  fibronectin leucine rich transmembrane protein 2
• GenBank acession
  • AF169676
• Locus
  14q31.3
• Discovery year
  1999-10-29
• Entrez gene record
  23768
• Pubmed identfication
  • 10644439
  • 16872596
• Classification
  • Fibronectin type III domain containing
• VEGA ID
  OTTHUMG00000171372

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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