Recombinant Human ERK3 / MAPK12 / P38-gamma Protein 50µg
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Catalog numberPKSH030317-50µg
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PricePlease ask
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Size50µg
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SynonymERK-6;ERK3;ERK6;MAPK12;P38GAMMA;PRKM12;SAPK-3;SAPK3
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ActivityNA
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SequenceMet1-Leu367
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Fusion tagNA
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AccessionP53778
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Expressed HostBaculovirus-Insect Cells
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ShippingKinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice.Shipment made at ambient temperature may seriously affect the activity of the ordered products.
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Purity＞95 % as determined by SDS-PAGE
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Endotoxin＜1.0 EU per µg as determined by the LAL method
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Stability and StorageSamples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Mol Mass42.1 kDa
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AP Mol Mass43 kDa
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FormulationSupplied as sterile 20mM Tris, 500mM NaCl, 10% glycerol, pH 8.0
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ReconstitutionPlease refer to it for detailed information.
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BackgroundERK3, also known as MAPK12 and p38-gamma, belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family and MAP kinase subfamily. ERK3 is highly expressed in skeletal muscle and heart. ERK3 is a serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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SourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolAHSA1, MAPK11, AIMP2, MAPK14, MAPK6, MAPK4, MAPK12
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Short nameRecombinant ERK3 / MAPK12 / P38-gamma Protein 50µg
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TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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SpeciesHuman, Humans
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Alternative nameRec. H. sapiens ERK3 / MAPK12 / P38-g Protein 50µg
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Alternative techniquerec
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Gene info
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Identity
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Gene
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Long gene nameactivator of HSP90 ATPase activity 1
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Synonyms gene
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Synonyms gene name
- chromosome 14 open reading frame 3
- AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-07-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemitogen-activated protein kinase 11
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Synonyms gene
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-04-28
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Entrez gene record
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Pubmed identfication
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Classification
- Mitogen-activated protein kinases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameaminoacyl tRNA synthetase complex interacting multifunctional protein 2
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Synonyms
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GenBank acession
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Locus
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Discovery year2009-05-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small nucleolar RNA protein coding host genes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemitogen-activated protein kinase 14
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Synonyms gene
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1995-01-24
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Mitogen-activated protein kinases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemitogen-activated protein kinase 6
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Synonyms gene
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-04-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Mitogen-activated protein kinases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemitogen-activated protein kinase 4
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Synonyms gene
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Synonyms
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GenBank acession
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Locus
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Discovery year1993-11-08
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Entrez gene record
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Pubmed identfication
-
RefSeq identity
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Classification
- Mitogen-activated protein kinases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemitogen-activated protein kinase 12
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Synonyms gene
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-04-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Mitogen-activated protein kinases
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VEGA ID
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
