Recombinant Human Endoglin / CD105 / ENG Protein (His tag)

• Catalog number
  PKSH031831-20µg
• Price
  Please ask
• Size
  20µg

• Synonym
  END;HHT1;ORW1
• Activity
  NA
• Sequence
  Met 1-Gly 586
• Fusion tag
  C-His
• Accession
  NP_001108225.1
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞95 % as determined by SDS-PAGE
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  62.3 kDa
• AP Mol Mass
  80-90 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  Endoglin, also known as CD105, is a type I  homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type I I receptor (TβRII) and activates the downstream signal pathways. In addition, in human umbilical vein endothelial cells, ALK-1 is also a receptor kinase for endoglin threonine phosphorylation, and mutations in either of the two genes result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful biomarker of neovascularization, and is associated with several solid tumor types.
• Technical data
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Endoglin   CD105   ENG   Protein   His   tag  
• Gene symbol
  ENG
• Short name
  Recombinant Endoglin / CD105 / ENG Protein (His tag)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens Endoglin / CD105 / endoglin Protein (histidine detection labelled)
• Alternative technique
  rec
• Alternative to gene target
  endoglin, END and HHT1 and ORW1, ENG and IDBG-86582 and ENSG00000106991 and 2022, transforming growth factor beta receptor, nuclei, Eng and IDBG-160783 and ENSMUSG00000026814 and 13805, ENG and IDBG-639059 and ENSBTAG00000008997 and 615844

Gene info

• Identity
  HGNC:3349
• Gene
  ENG
• Long gene name
  endoglin
• Synonyms gene
  • ORW1
  • ORW
• Synonyms gene name
  • Osler-Rendu-Weber syndrome 1
• Synonyms
  • END
  • HHT1
  • CD105
• GenBank acession
  • AF035753
• Locus
  9q34.11
• Discovery year
  1993-03-03
• Entrez gene record
  2022
• Pubmed identfication
  • 8404038
  • 10548503
• Classification
  • CD molecules
• VEGA ID
  OTTHUMG00000020723
• Locus Specific Databases
  • Hereditary Hemorrhagic Telangiectasia (HHT) Mutation Database
  • LRG_589

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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