Recombinant Human EDNRB / Endothelin B Receptor Protein (Fc tag) 100µg
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Catalog number
PKSH030546-100µg
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Price
Please ask
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Size
100µg
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Synonym
ABCDS;ET-B;ET-BR;ETB;ETBR;ETRB;HSCR;HSCR2;WS4A
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Activity
NA
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Sequence
Met1-Lys101
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Fusion tag
C-Fc
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Accession
NP_000106.1
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Expressed Host
HEK293 Cells
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Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
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Purity
> 85 % as determined by SDS-PAGE
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Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
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Stability and Storage
Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Mol Mass
34.4 kDa
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AP Mol Mass
47.5 and 43.7 kDa
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Formulation
Lyophilized from sterile PBS, pH 7.4
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Reconstitution
Please refer to it for detailed information.
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Background
The hypermethylation of EDNRB gene was remarkably related to infiltration and metastasis of gastric cancer and may attribute to the tumor progression. EDNRB is a new candidate tumor suppressor gene which is often down-regulated or even silenced by promoter hypermethylation in various human cancers. Low EDNRB expression played a role in the progression of ACC tumors. The autosomal recessive mutation in EDNRB may underlie a part of WS1 with the current diagnostic criteria, and supported that Hirschsprung's disease is a multifactorial genetic disease which requires additional factors.
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Description
The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
EDNRB-AS1, EDNRB
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Short name
Recombinant EDNRB / Endothelin B Receptor Protein (Fc tag) 100µg
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Technique
Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
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Label
Fc Tag
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Species
Human, Humans
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Alternative name
Rec. H. sapiens endothelin receptor classification B / Endothelin B Receptor Protein (fragment c detection labelled) 100µg
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Alternative technique
rec
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Alternative to gene target
endothelin receptor type B, ABCDS and ET-B and ET-BR and ETB and ETBR and ETRB and HSCR and HSCR2 and WS4A, EDNRB and IDBG-40388 and ENSG00000136160 and 1910, type 1 angiotensin receptor binding, nuclei, Ednrb and IDBG-185332 and ENSMUSG00000022122 and 13618, EDNRB and IDBG-631994 and ENSBTAG00000005299 and 281750
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Gene info
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Identity
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Gene
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Long gene name
EDNRB antisense RNA 1
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GenBank acession
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Locus
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Discovery year
2013-08-15
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Entrez gene record
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RefSeq identity
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Classification
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VEGA ID
Gene info
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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