Recombinant Human DNA Fragmentation Factor Subunit α/DFFA/DFF45/ICAD Protein(N-6His) 50µg
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Catalog number
PKSH032359-50µg
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Price
Please ask
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Size
50µg
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Synonym
DNA Fragmentation Factor Subunit Alpha; DNA Fragmentation Factor 45 kDa Subunit; DFF-45; Inhibitor of CAD; ICAD; DFFA; DFF1; DFF45; H13
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Activity
NA
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Sequence
Met1-Thr331
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Fusion tag
N-6His
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Accession
O00273
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Expressed Host
E.coli
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Shipping
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
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Purity
＞95% as determined by reducing SDS-PAGE.
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Endotoxin
＜1.0 EU per µg as determined by LAL test.
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Stability and Storage
Store at < -20℃, stable for 6 monthshs after receipt.Please minimize freeze-thaw cycles
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Mol Mass
38.7 kDa
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AP Mol Mass
42 kDa
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Formulation
Supplied as a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
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Reconstitution
Please refer to it for detailed information.
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Background
DNA Fragmentation Factor Subunit Alpha (DFFA). DFFA exists as a heterodimer (DFF) with DFFB. DFF is activated once DFFA is cleaved by Caspase-3. The cleaved fragments of DFFA detach from DFFB (the active component of DFF), which in turn triggers DNA fragmentation as well as chromatin condensation during apoptosis. A reduced level of DFFA detected in ovarian endometriosis may be a part of an apoptosis-resistant mechanism enhancing the disease progression.
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Description
Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
DFFA, PRKDC, HLA-DOA
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Short name
Recombinant DNA Fragmentation Factor Subunit α/DFFA/DFF45/ICAD Protein(N-6His) 50µg
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Technique
Recombinant, dna, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Species
Human, Humans
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Alternative name
Rec. H. sapiens Desoxyribonucleic acid Fragmentation Factor functionnal sequence α/Desoxyribonucleic acid fragmentation factor, 45kDa, alpha polypeptide/DFF45/ICAD Protein(N-6His) 50µg
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Alternative technique
rec
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Alternative to gene target
DNA fragmentation factor, 45kDa, alpha polypeptide, DFF-45 and DFF1 and ICAD, DFFA and IDBG-89047 and ENSG00000160049 and 1676, protein binding, nuclei, Dffa and IDBG-204894 and ENSMUSG00000028974 and 13347
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Gene info
Gene info
Gene info
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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