Recombinant Human CTLA4 / CD152 Protein (His tag)

• Catalog number
  PKSH031232-100µg
• Price
  Please ask
• Size
  100µg

• Synonym
  ALPS5;CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;IDDM12
• Activity
  Measured by its binding ability in a functional ELISA.2. Immobilized human CTLA4 at 10 μg/mL (100 μl/well) can bind human B7-1/Fc, The EC50 of human B7-1/Fc (cat: 10698-H03H is 14 ng/mL.3. Immobilized human CTLA4 at 10 μg/mL (100 μl/well) can bind human B7-2/Fch, The EC50 of human B7-2/Fch is 53 ng/mL.
• Sequence
  Met 1-Phe 162
• Fusion tag
  C-His
• Accession
  NP_005205.2
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞90 % as determined by SDS-PAGE
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  15 kDa
• AP Mol Mass
  15 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).Immune CheckpointImmune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IP Antibodies   Immune Checkpoint Detection: WB AntibodiesImmune Checkpoint Proteins   CTLA4 / CD152 Immune Checkpoint ProteinsImmune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets Immunotherapy   Cancer Immunotherapy   Targeted Therapy
• Technical data
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CTLA4   CD152   Protein   His   tag  
• Gene symbol
  CTLA4
• Short name
  Recombinant CTLA4 / CD152 Protein (His tag)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens cytotoxic T-lymphocyte-associated protein 4 / CD152 Protein (histidine detection labelled)
• Alternative technique
  rec
• Alternative to gene target
  cytotoxic T-lymphocyte-associated protein 4, CD and CD152 and CELIAC3 and CTLA-4 and GRD4 and GSE and IDDM12, CTLA4 and IDBG-79215 and ENSG00000163599 and 1493, protein binding, Cell surfaces, Ctla4 and IDBG-159662 and ENSMUSG00000026011 and 12477, CTLA-4 and IDBG-643375 and ENSBTAG00000013170 and 281732

Gene info

• Identity
  HGNC:2505
• Gene
  CTLA4
• Long gene name
  cytotoxic T-lymphocyte associated protein 4
• Synonyms gene
  • CELIAC3
  • IDDM12
• Synonyms gene name
  • celiac disease 3
  • insulin-dependent diabetes mellitus 12
• Synonyms
  • CD152
  • CD
  • GSE
  • CTLA-4
• Locus
  2q33.2
• Discovery year
  1989-05-25
• Entrez gene record
  1493
• Pubmed identfication
  • 3220103
  • 8817351
• RefSeq identity
  • NM_005214
• Classification
  • V-set domain containing
  • CD molecules
• VEGA ID
  OTTHUMG00000132877
• Locus Specific Databases
  • LRG_1220

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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