Recombinant Human CD6 / Cluster of Differentiation 6 Protein (Fc Tag) 100µg

• Catalog number
  PKSH030430-100µg
• Price
  Please ask
• Size
  100µg

• Synonym
  TP120
• Activity
  Measured by the ability of the immobilized protein to support the adhesion of Jurkat human acute T cell leukemia cells.When 8×10E4 cells/well are added to CD6-Fc coated plates (10 μg/mL, 100 μL/well), approximately >70% will adhere after 60 minutes at 37℃.
• Sequence
  Met1-Glu398
• Fusion tag
  C-Fc
• Accession
  NP_006716.3
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞95 % as determined by SDS-PAGE.
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method.
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  67.3 kDa
• AP Mol Mass
  67.3 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Reconstitution
  Please refer to it for detailed information.
• Background
  T-cell differentiation antigen CD6, also known as TP120 and CD6, is a single-pass type I membrane protein which contains three SRCR domains. CD6 / TP120 is a cell surface glycoprotein expressed primarily on T cells, it may function as a costimulatory molecule and may play a role in autoreactive immune responses. CD6 / TP120 is expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. CD6 ligand termed CD166 (previously known as activated leukocyte cell adhesion molecule, ALCAM ) has been identified and shown to be expressed on activated T cells, B cells, thymic epithelium, keratinocytes, and in rheumatoid arthritis synovial tissue. CD6 / TP120 binds to activated leukocyte cell adhesion molecule ( CD166 ), and is considered as a costimulatory molecule involved in lymphocyte activation and thymocyte development. CD6 / TP120 partially associates with the TCR / CD3 complex and colocalizes with it at the center of the mature immunological synapse (IS) on T lymphocytes. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional avidity of selection in both man and mouse.
• Product URL
• PDF URL
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CD6   Cluster   Differentiation   Protein   Tag   100µg  
• Gene symbol
  CD6
• Short name
  Recombinant CD6 / Cluster of Differentiation 6 Protein (Fc Tag) 100µg
• Technique
  Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  Fc Tag
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens CD6 molecule / Cluster on Differentiation 6 Protein (fragment c detection labelled) 100µg
• Alternative technique
  rec
• Alternative to gene target
  CD6 molecule, TP120, CD6 and IDBG-49617 and ENSG00000013725 and 923, protein binding, Plasma membranes, Cd6 and IDBG-145044 and ENSMUSG00000024670 and 12511, CD6 and IDBG-643095 and ENSBTAG00000018367 and 282881

Gene info

• Identity
  HGNC:1691
• Gene
  CD6
• Long gene name
  CD6 molecule
• Synonyms gene name
  • CD6 antigen
• Synonyms
  • Tp120
• Locus
  11q12.2
• Discovery year
  1997-07-04
• Entrez gene record
  923
• Pubmed identfication
  • 9013954
• RefSeq identity
  • NM_006725
• Classification
  • Scavenger receptor cysteine rich domain containing
  • CD molecules
• VEGA ID
  OTTHUMG00000167823

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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