Recombinant Human CD247 / CD3-ZETA Protein (GST tag)

• Catalog number
  PKSH030713-50µg
• Price
  Please ask
• Size
  50µg

• Synonym
  CD3-ZETA;CD3H;CD3Q;CD3Z;IMD25;T3Z;TCRZ
• Activity
  NA
• Sequence
  Arg52-Arg164
• Fusion tag
  N-GST
• Accession
  P20963-1
• Expressed Host
  E. coli
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞92 % as determined by SDS-PAGE
• Endotoxin
  Please contact us for more information.
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  40.2 kDa
• AP Mol Mass
  28-43 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  CD247, also known as CD3-ZETA, belongs to the CD3Z/FCER1G family. It contains 3 ITAM domains. As a -cell receptor zeta, CD247 forms the T-cell receptor-CD3 complex together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and –epsilon. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for CD247 gene. Defects in CD247 can cause immunodeficiency due to defect in CD3-zeta. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens. CD247 may play a role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.
• Technical data
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CD247   CD3-ZETA   Protein   GST   tag  
• Gene symbol
  MGST3, PSMA5, CD247, AP5Z1, S100Z, EIF3D, DGKZ, GPAT4, YWHAZ, IL37
• Short name
  Recombinant CD247 / CD3-ZETA Protein (GST tag)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  tag
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens CD247 molecule / CD3-ZETA Protein (GST detection labelled)
• Alternative technique
  rec
• Alternative to gene target
  CD247 molecule, CD3-ZETA and CD3H and CD3Q and CD3Z and IMD25 and T3Z and TCRZ, CD247 and IDBG-104547 and ENSG00000198821 and 919, protein homodimerization activity, Plasma membranes, Cd247 and IDBG-202777 and ENSMUSG00000005763 and 12503, CD247 and IDBG-629556 and ENSBTAG00000012700 and 281056

Gene info

• Identity
  HGNC:7064
• Gene
  MGST3
• Long gene name
  microsomal glutathione S-transferase 3
• Synonyms
  • GST-III
• Synonyms name
  • microsomal glutathione S-transferase III
  • microsomal GST-3
  • microsomal GST-III
• GenBank acession
  • AF026977
• Locus
  1q24.1
• Discovery year
  1997-10-16
• Entrez gene record
  4259
• Pubmed identfication
  • 9278457
• RefSeq identity
  • NM_004528
• Classification
  • Microsomal glutathione S-transferases
• VEGA ID
  OTTHUMG00000034627

Gene info

• Identity
  HGNC:9534
• Gene
  PSMA5
• Long gene name
  proteasome 20S subunit alpha 5
• Synonyms gene name
  • proteasome (prosome, macropain) subunit, alpha type, 5
  • proteasome subunit alpha 5
• Synonyms
  • ZETA
• GenBank acession
  • X61970
• Locus
  1p13.3
• Discovery year
  1995-05-03
• Entrez gene record
  5686
• Pubmed identfication
  • 1888762
• RefSeq identity
  • NM_002790
• Classification
  • Proteasome
• VEGA ID
  OTTHUMG00000012001

Gene info

• Identity
  HGNC:1677
• Gene
  CD247
• Long gene name
  CD247 molecule
• Synonyms gene
  • CD3Z
• Synonyms gene name
  • CD3z antigen, zeta polypeptide (TiT3 complex)
  • CD247 antigen
• Synonyms
  • CD3H
  • CD3Q
• Synonyms name
  • T-cell surface glycoprotein CD3 zeta chain
• GenBank acession
  • BC025703
• Locus
  1q24.2
• Discovery year
  1989-04-06
• Entrez gene record
  919
• Pubmed identfication
  • 2974162
• RefSeq identity
  • NM_198053
• Classification
  • CD molecules
• VEGA ID
  OTTHUMG00000034593
• Locus Specific Databases
  • CD247base: Mutation registry for Autosomal recessive CD3Zeta deficiency
  • LRG_36

Gene info

• Identity
  HGNC:22197
• Gene
  AP5Z1
• Long gene name
  adaptor related protein complex 5 subunit zeta 1
• Synonyms gene
  • KIAA0415
• Synonyms gene name
  • KIAA0415
  • adaptor-related protein complex 5, zeta 1 subunit
  • adaptor related protein complex 5 zeta 1 subunit
• Synonyms
  • SPG48
  • zeta
• GenBank acession
  • AB007875
• Locus
  7p22.1
• Discovery year
  2007-07-23
• Entrez gene record
  9907
• Pubmed identfication
  • 20613862
  • 22022230
• Classification
  • Adaptor related protein complex 5
  • Armadillo like helical domain containing
• VEGA ID
  OTTHUMG00000151754
• Locus Specific Databases
  • LRG_1247

Gene info

• Identity
  HGNC:30367
• Gene
  S100Z
• Long gene name
  S100 calcium binding protein Z
• Synonyms gene name
  • S100 calcium binding protein, zeta
• Synonyms
  • Gm625
  • S100-zeta
• GenBank acession
  • AF437876
• Locus
  5q13.3
• Discovery year
  2004-09-22
• Entrez gene record
  170591
• Pubmed identfication
  • 11747429
• RefSeq identity
  • NM_130772
• Classification
  • S100 calcium binding proteins
  • EF-hand domain containing
• VEGA ID
  OTTHUMG00000162441

Gene info

• Identity
  HGNC:3278
• Gene
  EIF3D
• Long gene name
  eukaryotic translation initiation factor 3 subunit D
• Synonyms gene
  • EIF3S7
• Synonyms gene name
  • eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDa
  • eukaryotic translation initiation factor 3, subunit D
• Synonyms
  • eIF3-p66
  • eIF3-zeta
• GenBank acession
  • U54558
• Locus
  22q12.3
• Discovery year
  1998-11-26
• Entrez gene record
  8664
• Pubmed identfication
  • 9341143
• Classification
  • Eukaryotic translation initiation factor 3
  • Armadillo like helical domain containing
• VEGA ID
  OTTHUMG00000150599

Gene info

• Identity
  HGNC:2857
• Gene
  DGKZ
• Long gene name
  diacylglycerol kinase zeta
• Synonyms gene name
  • diacylglycerol kinase, zeta 104kDa
• Synonyms
  • DAGK5
  • hDGKzeta
  • DGK-ZETA
  • DAGK6
• GenBank acession
  • U51477
• Locus
  11p11.2
• Discovery year
  1998-10-02
• Entrez gene record
  8525
• Pubmed identfication
  • 8626588
• RefSeq identity
  • NM_001105540
• Classification
  • Diacylglycerol kinases
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000166437

Gene info

• Identity
  HGNC:20880
• Gene
  GPAT4
• Long gene name
  glycerol-3-phosphate acyltransferase 4
• Synonyms gene
  • AGPAT6
• Synonyms gene name
  • 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)
  • 1-acylglycerol-3-phosphate O-acyltransferase 6
• Synonyms
  • DKFZp586M1819
  • LPAAT-zeta
  • TSARG7
• Synonyms name
  • lysophosphatidic acid acyltransferase, zeta
• GenBank acession
  • AF406612
• Locus
  8p11.21
• Discovery year
  2005-07-18
• Entrez gene record
  137964
• Pubmed identfication
  • 12938015
  • 18238778
• RefSeq identity
  • NM_178819
• Classification
  • Glycerol-3-phosphate acyltransferases
  • 1-acylglycerol-3-phosphate O-acyltransferases
• VEGA ID
  OTTHUMG00000164082

Gene info

• Identity
  HGNC:12855
• Gene
  YWHAZ
• Long gene name
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
• Synonyms gene
  • YWHAD
• Synonyms gene name
  • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide
  • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
• Synonyms
  • KCIP-1
  • 14-3-3-zeta
• Synonyms name
  • 14-3-3 zeta
  • 14-3-3 delta
• GenBank acession
  • U28964
• Locus
  8q22.3
• Discovery year
  1993-09-20
• Entrez gene record
  7534
• Pubmed identfication
  • 8617504
  • 7890696
• RefSeq identity
  • NM_145690
• Classification
  • 14-3-3 phospho-serine/phospho-threonine binding proteins
• VEGA ID
  OTTHUMG00000134291

Gene info

• Identity
  HGNC:15563
• Gene
  IL37
• Long gene name
  interleukin 37
• Synonyms gene
  • IL1F7
• Synonyms gene name
  • interleukin 1 family, member 7 (zeta)
• Synonyms
  • FIL1
  • FIL1Z
  • FIL1(ZETA)
  • IL-1H4
  • IL-1RP1
  • IL-1F7
• Synonyms name
  • interleukin 1, zeta
  • interleukin-1 homolog 4
  • interleukin-1-related protein
• GenBank acession
  • AF201832
• Locus
  2q14.1
• Discovery year
  2002-08-02
• Entrez gene record
  27178
• Pubmed identfication
  • 10625660
  • 10512743
  • 12496389
• RefSeq identity
  • NM_014439
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000131345

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

Similar products