Recombinant Human CD20 / MS4A1 Protein (aa 213-297, His tag)

• Catalog number
  PKSH031312-10µg
• Price
  Please ask
• Size
  10µg

• Synonym
  B1;Bp35;CD20;CVID5;LEU-16;MS4A1;MS4A2;S7
• Activity
  NA
• Sequence
  Glu213-Pro297
• Fusion tag
  N-His
• Accession
  NP_068769.2
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞83 % as determined by SDS-PAGE
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  12.1 kDa
• AP Mol Mass
  23 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  CD20 (membrane-spanning 4-domains, subfamily A, member 1), also known as MS4A1, is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. CD20 / MS4A1 is expressed on all stages of B cell development except the first and last. CD20 / MS4A1 is present from pre-pre B cells through memory cells, but not on either pro-B cells or plasma cells. It is a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. CD20 / MS4A1may be involved in the regulation of B-cell activation and proliferation. Defects in CD20 / MS4A1 are the cause of immunodeficiency common variable type 5(CVID5). CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy
• Technical data
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CD20   MS4A1   Protein   213-297   His   tag  
• Gene symbol
  MS4A1, MIR297, MIR181A1
• Short name
  Recombinant CD20 / MS4A1 Protein (aa 213-297, His tag)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens CD20 / membrane-spanning 4-domains, subfamily A, member 1 Protein (aa 213-297, histidine detection labelled)
• Alternative technique
  rec
• Alternative to gene target
  membrane-spanning 4-domains, subfamily A, member 1, B1 and Bp35 and CD20 and CVID5 and LEU-16 and MS4A2 and S7, MS4A1 and IDBG-49101 and ENSG00000156738 and 931, MHC class II protein complex binding, Extracellular, Ms4a1 and IDBG-146027 and ENSMUSG00000024673 and 12482, BT.53744 and IDBG-638183 and ENSBTAG00000004580 and 505653

Gene info

• Identity
  HGNC:7315
• Gene
  MS4A1
• Long gene name
  membrane spanning 4-domains A1
• Synonyms gene
  • CD20
• Synonyms gene name
  • membrane-spanning 4-domains, subfamily A, member 1
• Synonyms
  • B1
  • Bp35
  • FMC7
• GenBank acession
  • M27394
• Locus
  11q12.2
• Discovery year
  1989-05-23
• Entrez gene record
  931
• Pubmed identfication
  • 2448768
• Classification
  • Membrane spanning 4-domains
  • CD molecules
• VEGA ID
  OTTHUMG00000167614
• Locus Specific Databases
  • LRG_140

Gene info

• Identity
  HGNC:33691
• Gene
  MIR297
• Long gene name
  microRNA 297
• Synonyms gene
  • MIRN297
• Synonyms
  • hsa-mir-297
• Locus
  4q25
• Discovery year
  2007-10-25
• Entrez gene record
  100126354
• RefSeq identity
  • NR_030643
• Classification
  • MicroRNAs

Gene info

• Identity
  HGNC:31590
• Gene
  MIR181A1
• Long gene name
  microRNA 181a-1
• Synonyms gene
  • MIRN213
  • MIRN181A1
• Synonyms gene name
  • microRNA 213
• Synonyms
  • hsa-mir-213
• Locus
  1q32.1
• Discovery year
  2004-04-23
• Entrez gene record
  406995
• RefSeq identity
  • NR_029626
• Classification
  • MicroRNA MIR181 family

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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