Recombinant Human CD180 / RP105 / LY64 Protein (His tag) 20µg

• Catalog number
  PKSH031138-20µg
• Price
  Please ask
• Size
  20µg

• Synonym
  LY64;Ly78;RP105
• Activity
  Measured by its binding ability in a functional ELISA. Immobilized human CD180 at 2 μg/ml (100 μl/well) can bind biotinylated mouse MD-1 with a linear ranger of 3.125-25 μg/ml.
• Sequence
  Met 1-Gly 626
• Fusion tag
  C-His
• Accession
  NP_005573.2
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞92 % as determined by SDS-PAGE
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  69 kDa
• AP Mol Mass
  90-100 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Reconstitution
  Please refer to it for detailed information.
• Background
  The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD180, also known as RP105, is a B-cell surface molecule belonging to the family of pathogen receptors, Toll-like receptors (TLR). CD180 has an extracellular leucine-rich repeats and a short cytoplasmic tail. CD180 / RP105 interact with an extracellular molecule named MD1 and then together form the cell surface receptor complex RP105 / MD1 which induces B-cell activation in humans and mice, leading to proliferation and up-regulation of a costimulatory molecule, B7.2 / CD86. CD180 / RP105 also has a role in LPS response because B cells lacking RP105 show hyporesponsiveness to LPS.
• Product URL
• PDF URL
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CD180   RP105   LY64   Protein   His   tag   20µg  
• Gene symbol
  CD180
• Short name
  Recombinant CD180 / RP105 / LY64 Protein (His tag) 20µg
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens CD180 molecule / RP105 / LY64 Protein (histidine detection labelled) 20µg
• Alternative technique
  rec
• Alternative to gene target
  CD180 molecule, LY64 and Ly78 and RP105, CD180 and IDBG-24968 and ENSG00000134061 and 4064, protein binding, Plasma membranes, Cd180 and IDBG-179053 and ENSMUSG00000021624 and 17079, BT.22214 and IDBG-628694 and ENSBTAG00000006360 and 539518

Gene info

• Identity
  HGNC:6726
• Gene
  CD180
• Long gene name
  CD180 molecule
• Synonyms gene
  • LY64
• Synonyms gene name
  • lymphocyte antigen 64 (mouse) homolog, radioprotective, 105kD
  • CD180 antigen
• Synonyms
  • RP105
  • Ly78
• GenBank acession
  • D83597
• Locus
  5q12.3
• Discovery year
  1996-05-07
• Entrez gene record
  4064
• Pubmed identfication
  • 9763566
  • 8975706
• RefSeq identity
  • NM_005582
• Classification
  • CD molecules
• VEGA ID
  OTTHUMG00000131229

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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