Recombinant Human CD147 / EMMPRIN / Basigin Protein

#

• Catalog number
  PKSH031783-20µg
• Price:

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• Size
  20µg

# #

• Synonym
  5F7;Basigin;CD147;EMMPRIN;M6;OK;TCSF
• Activity
  NA
• Sequence
  Met 1-His 205
• Fusion tag
  NA
• Accession
  NP_940991.1
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞97 % as determined by SDS-PAGE and SEC-HPLC Analysis.
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  20.7 kDa
• AP Mol Mass
  35-38 kDa
• Formulation
  Lyophilized from sterile 50mM Tris, 100mM NaCl, pH 8.0
• Background
  CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence variants. It is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis, embryo implantation, neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Furthermore, CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction. Recently, CD147 displays increased expression in many cancers, and it has been previously demonstrated to participate in cancer metastasis and progression. Thus, CD147 and its antibody are used as an effective treatment for malignant cancers.
• Technical data
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

#

• Gene target
  CD147   EMMPRIN   Basigin   Protein  
• Gene symbol
  BSG
• Short name
  Recombinant CD147 / EMMPRIN / Basigin Protein
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens CD147 / EMMPRIN / Basigin Protein
• Alternative technique
  rec

Gene info

• Identity
  HGNC:1116
• Gene
  BSG
• Long gene name
  basigin (Ok blood group)
• Synonyms gene
  • OK
• Synonyms gene name
  • basigin
• Synonyms
  • EMMPRIN
  • CD147
  • EMPRIN
• Synonyms name
  • Ok blood group
  • extracellular matrix metalloproteinase inducer
  • Tumor cell-derived collagenase stimulatory factor
• GenBank acession
  • L10240
• Locus
  19p13.3
• Discovery year
  1993-10-25
• Entrez gene record
  682
• Pubmed identfication
  • 8404035
  • 7812975
• RefSeq identity
  • NM_001728
• Classification
  • Basigin family
  • I-set domain containing
  • Blood group antigens
  • CD molecules
• VEGA ID
  OTTHUMG00000177718
• Locus Specific Databases
  • Blood Group Antigen Mutation Database
  • LRG_816

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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