Recombinant Human Carnosine Dipeptidase 1 Protein

• Catalog number
  PKSH031891-10µg
• Price
  Please ask
• Size
  10µg

• Synonym
  Beta-Ala-His Dipeptidase; CNDP Dipeptidase 1; Carnosine Dipeptidase 1; Glutamate Carboxypeptidase-Like Protein 2; Serum Carnosinase; CNDP1; CN1; CPGL2
• Activity
  Measured by its ability to cleave carnosine (β­Ala­L­His) in a two­step assay.The specific activity is > 250 pmoles/min/μg.
• Sequence
  Pro28-His507
• Fusion tag
  C-6His
• Accession
  NP_116038.4
• Expressed Host
  Human cells
• Shipping
  The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
• Purity
  ＞95% as determined by reducing SDS-PAGE.
• Endotoxin
  ＜1.0 EU per µg as determined by LAL test.
• Stability and Storage
  Store at < -20℃, stable for 6 monthshs after receipt.Please minimize freeze-thaw cycles
• Mol Mass
  54.9 kDa
• AP Mol Mass
  68 kDa
• Formulation
  Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 7.5.
• Background
  Carnosine Dipeptidase 1 (CNDP1) belongs to the M20 metalloprotease family. CNDP1 is specifically expressed in the brain, serum and adult nervous central system. It is identified as human carnosinase. CNDP1 contains trinucleotide (CTG) repeat length polymorphism in the coding region and is inhibited by the metal chelator 1,10-o-phenantrolin. In addition, CNDP1 can hydrolyse the beta-Ala|-His dipeptide (carnosine), anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine. CNDP1 deficiency has been associated with homocarnosinosis disease.
• Technical data
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Carnosine   Dipeptidase   Protein  
• Gene symbol
  CNDP1
• Short name
  Recombinant Carnosine Dipeptidase 1 Protein
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens Carnosine Dipeptidase 1 Protein
• Alternative technique
  rec

Gene info

• Identity
  HGNC:20675
• Gene
  CNDP1
• Long gene name
  carnosine dipeptidase 1
• Synonyms gene name
  • carnosine dipeptidase 1 (metallopeptidase M20 family)
• Synonyms
  • MGC10825
  • CN1
  • CPGL2
  • HsT2308
• Synonyms name
  • carnosinase 1
  • glutamate carboxypeptidase-like protein 2
  • beta-Ala-His dipeptidase
• Locus
  18q22.3
• Discovery year
  2004-04-14
• Entrez gene record
  84735
• Pubmed identfication
  • 12473676
• RefSeq identity
  • NM_032649
• Classification
  • M20 metallopeptidases
• VEGA ID
  OTTHUMG00000132852

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

Similar products