Recombinant Human CALR / Calreticulin Protein (His tag) 50µg

• Catalog number
  PKSH030606-50µg
• Price
  Please ask
• Size
  50µg

• Synonym
  cC1qR;CRT;HEL-S-99n;RO;SSA
• Activity
  NA
• Sequence
  Met1-Ala413
• Fusion tag
  C-His
• Accession
  P27797
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞95 % as determined by SDS-PAGE
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  47.4 kDa
• AP Mol Mass
  58 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Reconstitution
  Please refer to it for detailed information.
• Background
  Calreticulin is a multifunctional protein. It acts as a main Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. Calreticulin binds Ca2+ ions (a second messenger in signal transduction), rendering it inactive. The Ca2+ is bound with low affinity, but high capacity, and can be released on a signal. Located in storage compartments associated with the endoplasmic reticulum, calreticulin also binds to misfolded proteins and prevents them from being exported from the endoplasmic reticulum to the golgi apparatus. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin reduces the binding of androgen receptor to its hormone-responsive DNA element and inhibits androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Therefore, calreticulin acts as a significant modulator of the regulation of gene transcription by nuclear hormone receptors.
• Product URL
• PDF URL
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CALR   Calreticulin   Protein   His   tag   50µg  
• Gene symbol
  CALR
• Short name
  Recombinant CALR / Calreticulin Protein (His tag) 50µg
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens calreticulin / Calreticulin Protein (histidine detection labelled) 50µg
• Alternative technique
  rec
• Alternative to gene target
  calreticulin, cC1qR and CRT and HEL-S-99n and RO and SSA, CALR and IDBG-31410 and ENSG00000179218 and 811, chaperone binding, nuclei, Calr and IDBG-174959 and ENSMUSG00000003814 and 12317, CALR and IDBG-642890 and ENSBTAG00000015114 and 281036

Gene info

• Identity
  HGNC:1455
• Gene
  CALR
• Long gene name
  calreticulin
• Synonyms
  • RO
  • SSA
  • cC1qR
  • CRT
  • FLJ26680
• Synonyms name
  • Sicca syndrome antigen A (autoantigen Ro; calreticulin)
  • autoantigen Ro
• GenBank acession
  • M84739
• Locus
  19p13.13
• Discovery year
  1990-09-10
• Entrez gene record
  811
• Pubmed identfication
  • 2365822
• RefSeq identity
  • NM_004343
• Classification
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000180574
• Locus Specific Databases
  • LRG_828

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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