Recombinant Human c-MET / HGFR Protein (His tag) 100µg

• Catalog number
  PKSH031482-100µg
• Price
  Please ask
• Size
  100µg

• Synonym
  AUTS9;c-Met;DFNB97;HGFR;RCCP2
• Activity
  Measured by its binding ability in a functional ELISA. Immobilized recombinant human HGF at 10 μg/ml (100 μl/well) can bind biotinylated c-Met. The EC50 of biotinylated c-Met is 5.28 μg/ml.
• Sequence
  Met 1-Thr 932
• Fusion tag
  C-His
• Accession
  NP_000236
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞90 % as determined by SDS-PAGE
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  103 kDa
• AP Mol Mass
  45 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Reconstitution
  Please refer to it for detailed information.
• Background
  Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that has been shown to be overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy
• Product URL
• PDF URL
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  c-MET   HGFR   Protein   His   tag   100µg  
• Gene symbol
  MET, SLTM, TRM-CAT4-3, TRM-CAT5-1, TRM-CAT3-2, TRM-CAT7-1, TRM-CAT5-2, TRM-CAT2-1, TRM-CAT3-1, TRM-CAT4-2
• Short name
  Recombinant c-MET / HGFR Protein (His tag) 100µg
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens c-MET / HGFR Protein (histidine detection labelled) 100µg
• Alternative technique
  rec

Gene info

• Identity
  HGNC:7029
• Gene
  MET
• Long gene name
  MET proto-oncogene, receptor tyrosine kinase
• Synonyms gene name
  • met proto-oncogene
• Synonyms
  • HGFR
  • RCCP2
  • DFNB97
• Synonyms name
  • hepatocyte growth factor receptor
• GenBank acession
  • M35073
• Locus
  7q31
• Discovery year
  1986-01-01
• Pubmed identfication
  • 1846706
  • 1611909
  • 25941349
• Classification
  • Receptor tyrosine kinases
  • IPT domain containing
• VEGA ID
  OTTHUMG00000023299
• Locus Specific Databases
  • LRG_662

Gene info

• Identity
  HGNC:20709
• Gene
  SLTM
• Long gene name
  SAFB like transcription modulator
• Synonyms
  • Met
  • FLJ13213
• GenBank acession
  • BC046119
• Locus
  15q22.1
• Discovery year
  2005-11-08
• Entrez gene record
  79811
• RefSeq identity
  • NM_024755
• Classification
  • RNA binding motif containing
• VEGA ID
  OTTHUMG00000074033

Gene info

• Identity
  HGNC:34959
• Gene
  TRM-CAT4-3
• Long gene name
  tRNA-Met (anticodon CAT) 4-3
• Synonyms gene
  • TRNAM20
• Synonyms gene name
  • transfer RNA methionine 20 (anticodon CAU)
  • transfer RNA-Met (CAT) 4-3
• Synonyms
  • tRNA-Met-CAT-4-3
• GenBank acession
  • HG983956
• Locus
  6p22.2
• Discovery year
  2008-08-29
• Entrez gene record
  107986682
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34869
• Gene
  TRM-CAT5-1
• Long gene name
  tRNA-Met (anticodon CAT) 5-1
• Synonyms gene
  • TRNAM16
• Synonyms gene name
  • transfer RNA methionine 16 (anticodon CAU)
  • transfer RNA-Met (CAT) 5-1
• Synonyms
  • tRNA-Met-CAT-5-1
• GenBank acession
  • HG983957
• Locus
  6p22.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189303
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34673
• Gene
  TRM-CAT3-2
• Long gene name
  tRNA-Met (anticodon CAT) 3-2
• Synonyms gene
  • TRNAM8
• Synonyms gene name
  • transfer RNA methionine 8 (anticodon CAU)
  • transfer RNA-Met (CAT) 3-2
• Synonyms
  • tRNA-Met-CAT-3-2
• GenBank acession
  • HG983953
• Locus
  6p22.1
• Discovery year
  2008-08-29
• Entrez gene record
  100189111
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34645
• Gene
  TRM-CAT7-1
• Long gene name
  tRNA-Met (anticodon CAT) 7-1
• Synonyms gene
  • TRNAM5
• Synonyms gene name
  • transfer RNA methionine 5 (anticodon CAU)
  • transfer RNA-Met (CAT) 7-1
• Synonyms
  • tRNA-Met-CAT-7-1
• GenBank acession
  • HG983959
• Locus
  6p11.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189085
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:54713
• Gene
  TRM-CAT5-2
• Long gene name
  tRNA-Met (anticodon CAT) 5-2
• Synonyms
  • tRNA-Met-CAT-5-2
• Locus
  6p22.2
• Discovery year
  2019-12-06
• Entrez gene record
  107986680
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34697
• Gene
  TRM-CAT2-1
• Long gene name
  tRNA-Met (anticodon CAT) 2-1
• Synonyms gene
  • TRNAM9
• Synonyms gene name
  • transfer RNA methionine 9 (anticodon CAU)
  • transfer RNA-Met (CAT) 2-1
• Synonyms
  • tRNA-Met-CAT-2-1
• GenBank acession
  • HG983951
• Locus
  16q22.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189135
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34779
• Gene
  TRM-CAT3-1
• Long gene name
  tRNA-Met (anticodon CAT) 3-1
• Synonyms gene
  • TRNAM12
• Synonyms gene name
  • transfer RNA methionine 12 (anticodon CAU)
  • transfer RNA-Met (CAT) 3-1
• Synonyms
  • tRNA-Met-CAT-3-1
• GenBank acession
  • HG983952
• Locus
  6p22.1
• Discovery year
  2008-08-29
• Entrez gene record
  100189216
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34922
• Gene
  TRM-CAT4-2
• Long gene name
  tRNA-Met (anticodon CAT) 4-2
• Synonyms gene
  • TRNAM19
• Synonyms gene name
  • transfer RNA methionine 19 (anticodon CAU)
  • transfer RNA-Met (CAT) 4-2
• Synonyms
  • tRNA-Met-CAT-4-2
• GenBank acession
  • HG983955
• Locus
  6p22.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189354
• Classification
  • Cytoplasmic transfer RNAs

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

Similar products