Recombinant Human AGER / RAGE Protein

• Catalog number
  PKSH031054-50µg
• Price
  Please ask
• Size
  50µg

• Synonym
  RAGE
• Activity
  Measured by its ability to compete with Biotinylated recombinant human AGER for binding to immobilized recombinant human Fc-S100B in a functional ELISA.2. Measured by its ability to compete with Biotinylated recombinant human AGER for binding to immobilized recombinant mouse S100B-Fc in a functional ELISA.3. Measured by its ability to compete with Biotinylated recombinant human AGER for binding to immobilized recombinant human S100A1-Fc in a functional ELISA.4. Measured by its ability to compete with Biotinylated recombinant human AGER for binding to immobilized recombinant human APP-Fc in a functional ELISA.
• Sequence
  Met1-Ala 344
• Fusion tag
  NA
• Accession
  NP_001127.1
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞95 % as determined by SDS-PAGE
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  35 kDa
• AP Mol Mass
  46-52 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  Receptor for Advanced Glycosylation End Products (RAGE, or AGER) is a member of the immunoglobulin super-family transmembrane proteins, as a signal transduction receptor which binds advanced glycation endproducts, certain members of the S100/calgranulin family of proteins, high mobility group box 1 (HMGB1), advanced oxidation protein products, and amyloid (beta-sheet fibrils). Initial studies investigating the role of RAGE in renal dysfunction focused on diabetes, neurodegenerative disorders, and inflammatory responses. However, RAGE also has roles in the pathogenesis of renal disorders that are not associated with diabetes, such as obesity-related glomerulopathy, doxorubicin-induced nephropathy, hypertensive nephropathy, lupus nephritis, renal amyloidosis, and ischemic renal injuries. RAGE represents an important factor in innate immunity against pathogens, but it also interacts with endogenous ligands, resulting in chronic inflammation. RAGE signaling has been implicated in multiple human illnesses, including atherosclerosis, arthritis, Alzheimer's disease, atherosclerosis and aging associated diseases.
• Technical data
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  AGER   RAGE   Protein  
• Gene symbol
  AGER, MOK
• Short name
  Recombinant AGER / RAGE Protein
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens advanced glycosylation end product-specific receptor / RAGE Protein
• Alternative technique
  rec
• Alternative to gene target
  advanced glycosylation end product-specific receptor, RAGE, AGER and IDBG-80463 and ENSG00000204305 and 177, S100 protein binding, Extracellular, Ager and IDBG-172144 and ENSMUSG00000015452 and 11596, AGER and IDBG-633065 and ENSBTAG00000014420 and 280986

Gene info

• Identity
  HGNC:320
• Gene
  AGER
• Long gene name
  advanced glycosylation end-product specific receptor
• Synonyms
  • RAGE
  • SCARJ1
  • sRAGE
• Synonyms name
  • receptor for advanced glycation end-products
• GenBank acession
  • M91211
• Locus
  6p21.32
• Discovery year
  1994-10-17
• Entrez gene record
  177
• Pubmed identfication
  • 7713518
• RefSeq identity
  • NM_001136
• Classification
  • Scavenger receptors
  • C2-set domain containing
• VEGA ID
  OTTHUMG00000031120

Gene info

• Identity
  HGNC:9833
• Gene
  MOK
• Long gene name
  MOK protein kinase
• Synonyms gene
  • RAGE
• Synonyms gene name
  • renal tumor antigen
• Synonyms
  • RAGE1
  • STK30
• GenBank acession
  • AB022694
• Locus
  14q32.31
• Discovery year
  1995-05-10
• Entrez gene record
  5891
• Pubmed identfication
  • 8781117
  • 10421840
• VEGA ID
  OTTHUMG00000164896

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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