Recombinant Human ADM / Adrenomedullin Protein (Fc tag)

• Catalog number
  PKSH031046-20µg
• Price
  Please ask
• Size
  20µg

• Synonym
  AM;PAMP
• Activity
  NA
• Sequence
  Tyr95-Tyr146
• Fusion tag
  N-Fc
• Accession
  P35318
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞93 % as determined by SDS-PAGE
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  38 kDa
• AP Mol Mass
  39 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  Adrenomedullin consists of 52 amino acids and is a member of the adrenomedullin family. It s a a hypotensive peptide and has 1 intramolecular disulfide bond. It seems that adrenomedullin has a slight homology with the calcitonin gene-related peptide. Adrenomedullin has a highly expression in pheochromocytoma and adrenal medulla. It also can be detected in lung, ventricle and kidney tissues. Adrenomedullin and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, adrenomedullin is diuretic and natriuretic, and both adrenomedullin and PAMP inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. It is believed that adrenomedullin functions through combinations of the calcitonin receptor like receptor and receptor activity-modifying proteins complexes, as well as CGRP receptors.
• Technical data
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  ADM   Adrenomedullin   Protein   tag  
• Gene symbol
  ADM, ADM-DT
• Short name
  Recombinant ADM / Adrenomedullin Protein (Fc tag)
• Technique
  Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  Fc Tag
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens adrenomedullin / Adrenomedullin Protein (fragment c detection labelled)
• Alternative technique
  rec
• Alternative to gene target
  adrenomedullin, AM and PAMP, ADM and IDBG-31636 and ENSG00000148926 and 133, adrenomedullin receptor binding, Extracellular, Adm and IDBG-206620 and ENSMUSG00000030790 and 11535, ADM and IDBG-633364 and ENSBTAG00000021048 and 280713

Gene info

• Identity
  HGNC:259
• Gene
  ADM
• Long gene name
  adrenomedullin
• Synonyms
  • AM
• GenBank acession
  • D14874
• Locus
  11p15.4
• Discovery year
  1994-12-15
• Entrez gene record
  133
• Pubmed identfication
  • 7688224
• RefSeq identity
  • NM_001124
• Classification
  • Neuropeptides
• VEGA ID
  OTTHUMG00000165907

Gene info

• Identity
  HGNC:55516
• Gene
  ADM-DT
• Long gene name
  ADM divergent transcript
• Locus
  11p15.4
• Discovery year
  2021-03-17
• Entrez gene record
  105376544
• Classification
  • Divergent transcripts

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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