Mouse ALK-6 / BMPR1B Protein (Fc Tag)

• Catalog number
  PKSM040925-20µg
• Price
  Please ask
• Size
  20µg

• Synonym
  Acvrlk6;AI385617;ALK-6;Alk6;AV355320;BMPR-1B;BMPR-IB;CFK-43a;SKR6
• Activity
  NA
• Sequence
  Lys14-Lys126
• Fusion tag
  C-Fc
• Accession
  NP_031586.1
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  > (88.3+9.9) % as determined by SDS-PAGE.
• Endotoxin
  < 1.0 EU per μg protein as determined by the LAL method.
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  39.4 kDa
• AP Mol Mass
  39.4 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  BMPR1B(bone morphogenetic protein receptor, type IB), also known as ALK6, is a a member of the bone morphogenetic protein (BMP) receptor family. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. BMPR1B is the major transducer of signals in precartilaginous condensations as demonstrated in experiments using constitutively active BMPR1B receptors. BMPR1B is a more effective trasducer of GDF5 than BMPR1A. Unlike BMPR1A null mice, which die at an early embryonic stage, BMPR1B null mice are viable.
• Technical data
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus

• Gene target
  ALK-6   BMPR1B   Protein   Tag  
• Gene symbol
  BMPR1B, BMPR1B-DT, ALK, ENPP7, TGFBR1, BMPR2, MIR1302-6, PIRC24, PIRC28, PIRC26
• Short name
  Mouse ALK-6 / BMPR1B Protein (Fc Tag)
• Technique
  Mouse, FC, mouses, Tags
• Host
  mouse
• Label
  Fc Tag
• Species
  Mouse, Mouses
• Alternative name
  Mouse anaplastic lymphoma receptor tyrosine kinase-6 / bone morphogenetic protein receptor, classification IB Protein (fragment c detection labelled)
• Alternative technique
  murine
• Alternative to gene target
  bone morphogenetic protein receptor, type IB, ALK-6 and ALK6 and CDw293, BMPR1B and IDBG-30667 and ENSG00000138696 and 658, transforming growth factor beta receptor activity, Plasma membranes, Bmpr1b and IDBG-196928 and ENSMUSG00000052430 and 12167, BMPR1B and IDBG-641011 and ENSBTAG00000002081 and 407128

Gene info

• Identity
  HGNC:1077
• Gene
  BMPR1B
• Long gene name
  bone morphogenetic protein receptor type 1B
• Synonyms gene name
  • bone morphogenetic protein receptor, type IB
• Synonyms
  • ALK6
  • CDw293
• GenBank acession
  • D89675
• Locus
  4q22.3
• Discovery year
  1997-03-19
• Entrez gene record
  658
• Pubmed identfication
  • 8140412
  • 9730621
• RefSeq identity
  • NM_001203
• Classification
  • CD molecules
  • Type 1 receptor serine/threonine kinases
• VEGA ID
  OTTHUMG00000130991

Gene info

• Identity
  HGNC:50864
• Gene
  BMPR1B-DT
• Long gene name
  BMPR1B divergent transcript
• Synonyms gene
  • BMPR1B-AS1
• Synonyms gene name
  • BMPR1B antisense RNA 1 (head to head)
• Synonyms
  • TCONS_00007797
• Locus
  4q22.3
• Discovery year
  2014-07-14
• Entrez gene record
  100507012
• Classification
  • Divergent transcripts
• VEGA ID
  OTTHUMG00000161193

Gene info

• Identity
  HGNC:427
• Gene
  ALK
• Long gene name
  ALK receptor tyrosine kinase
• Synonyms gene name
  • anaplastic lymphoma kinase (Ki-1)
  • anaplastic lymphoma receptor tyrosine kinase
• Synonyms
  • CD246
  • ALK1
• GenBank acession
  • D45915
• Locus
  2p23.2-p23.1
• Discovery year
  1993-08-24
• Entrez gene record
  238
• Pubmed identfication
  • 8122112
• RefSeq identity
  • NM_004304
• Classification
  • Receptor tyrosine kinases
  • CD molecules
• VEGA ID
  OTTHUMG00000152034
• Locus Specific Databases
  • LRG_488

Gene info

• Identity
  HGNC:23764
• Gene
  ENPP7
• Long gene name
  ectonucleotide pyrophosphatase/phosphodiesterase 7
• Synonyms
  • alk-SMase
  • NPP7
• Synonyms name
  • alkaline sphingomyelinase
• GenBank acession
  • AY230663
• Locus
  17q25.3
• Discovery year
  2004-04-29
• Entrez gene record
  339221
• Pubmed identfication
  • 12885774
• RefSeq identity
  • NM_178543
• Classification
  • Ectonucleotide pyrophosphatase/phosphodiesterase family
• VEGA ID
  OTTHUMG00000177462

Gene info

• Identity
  HGNC:11772
• Gene
  TGFBR1
• Long gene name
  transforming growth factor beta receptor 1
• Synonyms gene
  • MSSE
  • ESS1
• Synonyms gene name
  • multiple self-healing squamous epithelioma
  • transforming growth factor beta receptor I
• Synonyms
  • ALK-5
  • ACVRLK4
  • ALK5
  • TBRI
  • TBR-i
• Synonyms name
  • activin A receptor type II-like kinase, 53kDa
• Locus
  9q22.33
• Discovery year
  1993-09-30
• Entrez gene record
  7046
• Pubmed identfication
  • 1319842
  • 8530052
  • 21358634
• Classification
  • Type 1 receptor serine/threonine kinases
• VEGA ID
  OTTHUMG00000020353
• Locus Specific Databases
  • LOVD - Center for Medical Genetics, Ghent, Belgium

Gene info

• Identity
  HGNC:1078
• Gene
  BMPR2
• Long gene name
  bone morphogenetic protein receptor type 2
• Synonyms gene
  • PPH1
• Synonyms gene name
  • primary pulmonary hypertension 1
  • bone morphogenetic protein receptor, type II (serine/threonine kinase)
  • bone morphogenetic protein receptor type II
• Synonyms
  • BRK-3
  • T-ALK
  • BMPR3
  • BMPR-II
• GenBank acession
  • Z48923
• Locus
  2q33.1-q33.2
• Discovery year
  1997-03-19
• Entrez gene record
  659
• Pubmed identfication
  • 7791754
• RefSeq identity
  • NM_001204
• Classification
  • Type 2 receptor serine/threonine kinases
• VEGA ID
  OTTHUMG00000133617
• Locus Specific Databases
  • LRG_712

Gene info

• Identity
  HGNC:35298
• Gene
  MIR1302-6
• Long gene name
  microRNA 1302-6
• Synonyms gene
  • MIRN1302-6
• Synonyms
  • hsa-mir-1302-6
• Locus
  7p21.1
• Discovery year
  2008-11-03
• Entrez gene record
  100302140
• RefSeq identity
  • NR_031635
• Classification
  • MicroRNA MIR1302 family

Gene info

• Identity
  HGNC:37528
• Gene
  PIRC24
• Long gene name
  piwi-interacting RNA cluster 24
• Locus
  6
• Discovery year
  2009-11-05
• Entrez gene record
  100313810
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37532
• Gene
  PIRC28
• Long gene name
  piwi-interacting RNA cluster 28
• Locus
  6
• Discovery year
  2009-11-05
• Entrez gene record
  100313893
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37530
• Gene
  PIRC26
• Long gene name
  piwi-interacting RNA cluster 26
• Locus
  6
• Discovery year
  2009-11-05
• Entrez gene record
  100313852
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

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