-
Long name
Rabbit Antibody against Mouse Tgfb1, HRP
-
Synonym name
Tgfb1 Mouse Antibody
-
Species reactivity
Mouse
-
Tested applications recommended dilutions
ELISA
-
Conjugation
HRP
-
Antibody isotype
IgG
-
UniProt ID
P04202
-
Format
Liquid, diluted in buffer
-
Buffer composition
Preservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
-
Purity
>95%
-
Purification method
Protein G purified
-
Antibody category
Polyclonal Antibodies
-
Immunogen type
Recombinant Mouse Transforming growth factor beta-1 protein (30-391AA)
-
Immunogen species
Mouse
-
Alias
Transforming growth factor beta-1TGF-beta-1,Tgfb1
-
Background
Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells (PubMed:18368049). Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus. Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (By similarity).
-
Clonality
Polyclonal antibody
-
Shipping and storage
Tgfb1 Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
-
Short name of the antigen
Transforming growth factor beta-1
-
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. This is against a protein of mus musculus directed antibody.
-
Properties
If you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. HRP conjugates are often primary rabbit polyclonal antibodies couples to the enzyme horseradish peroxidase (HRP), found in the roots of horseradish. Also monoclonal HRP conjugates are often used for Western Blot.
-
Additional conjugation
HRP Conjugated
-
Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
-
Latin name
Mus musculus, Oryctolagus cuniculus
-
About
Rabbits are used for polyclonal antibody production by Cusabio. Rabbit antibodies are very stable and can be stored for several days at room temperature. Cusabio adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
-
French translation
anticorps
-
Gene target
-
Gene symbol
TIAF1, TGFB1
-
Short name
Anti-Tgfb1
-
Technique
anti mouse, Antibody, Rabbit, Mouse, anti, antibody to, anti mouse antibodies, antibodies against human proteins, antibodies for, mouses
-
Host
Rabbit, Rabbits
-
Label
HRP
-
Species
Mouse, Mouses
-
Alternative name
Tgfb1 Antibody,HRP conjugated
-
Alternative technique
antibodies, rabbit-anti, murine
-
Alternative to gene target
transforming growth factor, beta 1, CED and DPD1 and LAP and TGFB and TGFbeta, TGFB1 and IDBG-52846 and ENSG00000105329 and 7040, protein N-terminus binding, nuclei, Tgfb1 and IDBG-158292 and ENSMUSG00000002603 and 21803, TGFB1 and IDBG-638417 and ENSBTAG00000020457 and 282089
-