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Long name
Rabbit Antibody against Human, Mouse TP53BP2, Non-conjugated
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Synonym name
TP53BP2 Human, Mouse Antibody
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Species reactivity
Human,Mouse
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Tested applications recommended dilutions
ELISA,WB;Recommended dilution:WB:1:200-1000
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Conjugation
Non-conjugated
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Antibody isotype
IgG
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UniProt ID
Q13625
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Format
Liquid, diluted in buffer
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Buffer composition
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Purity
>95%
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Purification method
Antigen Affinity Purified Antibodies
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Antibody category
Polyclonal Antibodies
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Immunogen type
Recombinant human Apoptosis-stimulating of p53 protein 2 protein (360-600AA)
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Immunogen species
Human
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Alias
Bcl2-binding protein,Bbp,Renal carcinoma antigen NY-REN-51,Tumor suppressor p53-binding protein 2,53BP2,p53-binding protein 2,p53BP2,TP53BP2,ASPP2, BBP
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Background
Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.
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Clonality
Polyclonal antibody
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Shipping and storage
TP53BP2 Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
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Properties
If you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin name
Mus musculus, Oryctolagus cuniculus
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About
Rabbits are used for polyclonal antibody production by Cusabio. Rabbit antibodies are very stable and can be stored for several days at room temperature. Cusabio adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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French translation
anticorps
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Gene target
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Gene symbol
TP53BP2
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Short name
Anti-TP53BP2
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Technique
anti human, Antibody, Rabbit, Mouse, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for, antibody Conjugates, mouses
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Host
Rabbit, Rabbits
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Species
Mouse, Humans, Mouses
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Alternative name
TP53BP2 Antibody
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Alternative technique
antibodies, rabbit-anti, murine
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Alternative to gene target
tumor protein p53 binding protein, 2, 53BP2 and ASPP2 and BBP and P53BP2 and PPP1R13A, TP53BP2 and IDBG-106878 and ENSG00000143514 and 7159, NF-kappaB binding, nuclei, Trp53bp2 and IDBG-207716 and ENSMUSG00000026510 and 209456, TP53BP2 and IDBG-630822 and ENSBTAG00000012781 and 514474
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