Rabbit Anti Human VAV3 Antibody-HRP
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Catalog numberCSB-PA892140LB01HU_50ug
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PricePlease ask
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Size50ug
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Long nameRabbit Antibody against Human VAV3, HRP
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Synonym nameVAV3 Human Antibody
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Species reactivityHuman
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Tested applications recommended dilutionsELISA
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ConjugationHRP
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Antibody isotypeIgG
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UniProt IDQ9UKW4
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FormatLiquid, diluted in buffer
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Buffer compositionPreservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
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Purity>95%
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Purification methodProtein G purified
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Antibody categoryPolyclonal Antibodies
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Immunogen typeRecombinant Human Guanine nucleotide exchange factor VAV3 protein (562-674AA)
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Immunogen speciesHuman
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AliasGuanine nucleotide exchange factor VAV3,VAV-3,VAV3
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BackgroundExchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity).
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ClonalityPolyclonal antibody
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Shipping and storageVAV3 Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
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Short name of the antigenGuanine nucleotide exchange factor VAV3
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
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PropertiesIf you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. HRP conjugates are often primary rabbit polyclonal antibodies couples to the enzyme horseradish peroxidase (HRP), found in the roots of horseradish. Also monoclonal HRP conjugates are often used for Western Blot. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional conjugationHRP Conjugated
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AboutRabbits are used for polyclonal antibody production by Cusabio. Rabbit antibodies are very stable and can be stored for several days at room temperature. Cusabio adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin nameOryctolagus cuniculus
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French translationanticorps
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Gene target
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Gene symbolVAV3, VAV3-AS1
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Short nameAnti-VAV3
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Techniqueanti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for
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HostRabbit, Rabbits
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LabelHRP
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SpeciesHuman, Humans
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Alternative nameVAV3 Antibody,HRP conjugated
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Alternative techniqueantibodies, rabbit-anti
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Alternative to gene targetvav 3 guanine nucleotide exchange factor, VAV3 and IDBG-100649 and ENSG00000134215 and 10451, metal ion binding, Plasma membranes, Vav3 and IDBG-188386 and ENSMUSG00000033721 and 57257, VAV3 and IDBG-635847 and ENSBTAG00000031575 and 521961
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Gene info
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Identity
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Gene
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Long gene namevav guanine nucleotide exchange factor 3
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Synonyms gene name
- vav 3 oncogene
- vav 3 guanine nucleotide exchange factor
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GenBank acession
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Locus
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Discovery year1999-07-07
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Entrez gene record
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RefSeq identity
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Classification
- Dbl family Rho GEFs
- Pleckstrin homology domain containing
- MicroRNA protein coding host genes
- SH2 domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameVAV3 antisense RNA 1
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Synonyms gene name
- VAV3 antisense RNA 1 (non-protein coding)
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GenBank acession
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Locus
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Discovery year2012-02-24
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Entrez gene record
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Classification
- Antisense RNAs
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data