Rabbit Anti Human RET Antibody-Non-conjugated
-
Catalog numberCSB-PA019572DSR2HU_100ul
-
PricePlease ask
-
Size100ul
-
-
Long nameRabbit Antibody against Human RET, Non-conjugated
-
Synonym nameRET Human Antibody
-
Species reactivityHuman
-
Tested applications recommended dilutionsELISA,IHC;Recommended dilution:IHC:1:20-1:200
-
ConjugationNon-conjugated
-
Antibody isotypeIgG
-
UniProt IDP07949
-
FormatLiquid, diluted in buffer
-
Buffer compositionPBS with 0.02% sodium azide, 50% glycerol, pH7.3.
-
Purity>95%
-
Purification methodAntigen Affinity Purified Antibodies
-
Antibody categoryPolyclonal Antibodies
-
Immunogen typeRecombinant human Proto-oncogene tyrosine-protein kinase receptor Ret protein (29-300AA)
-
Immunogen speciesHuman
-
AliasCadherin family member 12,Proto-oncogene c-Ret,RET,CDHF12, CDHR16,PTC,RET51
-
BackgroundReceptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration.
-
ClonalityPolyclonal antibody
-
Shipping and storageRET Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
-
DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
-
PropertiesIf you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
-
AboutRabbits are used for polyclonal antibody production by Cusabio. Rabbit antibodies are very stable and can be stored for several days at room temperature. Cusabio adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
-
Latin nameOryctolagus cuniculus
-
French translationanticorps
-
Gene target
-
Gene symbolGOLGA5, RET
-
Short nameAnti-RET
-
Techniqueanti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for, antibody Conjugates
-
HostRabbit, Rabbits
-
SpeciesHuman, Humans
-
Alternative nameRET Antibody
-
Alternative techniqueantibodies, rabbit-anti
-
Alternative to gene targetret proto-oncogene, CDHF12 and CDHR16 and HSCR1 and MEN2A and MEN2B and MTC1 and PTC and RET-ELE1 and RET51, RET and IDBG-71064 and ENSG00000165731 and 5979, transferase activity, Plasma membranes, Ret and IDBG-181393 and ENSMUSG00000030110 and 19713, RET and IDBG-628722 and ENSBTAG00000000570 and 515924
-
Gene info
-
Identity
-
Gene
-
Long gene namegolgin A5
-
Synonyms gene name
- golgi autoantigen, golgin subfamily a, 5
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1999-04-28
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Golgins
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameret proto-oncogene
-
Synonyms gene
-
Synonyms gene name
- multiple endocrine neoplasia and medullary thyroid carcinoma 1
- Hirschsprung disease 1
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1990-07-15
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Cadherin related
- Receptor tyrosine kinases
-
VEGA ID
-
Locus Specific Databases
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data