Rabbit Anti Human RAC1 Antibody-Non-conjugated
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Catalog numberCSB-PA04329A0Rb_100ug
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PricePlease ask
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Size100ug
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Long nameRabbit Antibody against Human RAC1, Non-conjugated
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Synonym nameRAC1 Human Antibody
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Species reactivityHuman
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Tested applications recommended dilutionsELISA,IHC,IF;Recommended dilution:IHC:1:20-1:200,IF:1:50-1:200
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ConjugationNon-conjugated
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Antibody isotypeIgG
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UniProt IDP63000
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FormatLiquid, diluted in buffer
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Buffer compositionPreservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
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Purity>95%
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Purification methodProtein G purified
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Antibody categoryPolyclonal Antibodies
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Immunogen typeRecombinant human Ras-related C3 botulinum toxin substrate 1 protein (11-185AA)
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Immunogen speciesHuman
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AliasRas-related C3 botulinum toxin substrate 1,Cell migration-inducing gene 5 protein,Ras-like protein TC25,p21-Rac1,RAC1,TC25,MIG5
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BackgroundPlasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3.
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ClonalityPolyclonal antibody
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Shipping and storageRAC1 Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
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Short name of the antigenRas-related C3 botulinum toxin substrate 1
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
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PropertiesIf you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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AboutRabbits are used for polyclonal antibody production by Cusabio. Rabbit antibodies are very stable and can be stored for several days at room temperature. Cusabio adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin nameOryctolagus cuniculus
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French translationanticorps
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Gene target
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Gene symbolRAC1, RNASE1
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Short nameAnti-RAC1
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Techniqueanti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for, antibody Conjugates
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HostRabbit, Rabbits
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SpeciesHuman, Humans
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Alternative nameRAC1 Antibody
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Alternative techniqueantibodies, rabbit-anti
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Alternative to gene targetras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1), p21-Rac1 and Rac-1 and TC-25, RAC1 and IDBG-8115 and ENSG00000136238 and 5879, Rho GDP-dissociation inhibitor binding, Plasma membranes, Rac1 and IDBG-207763 and ENSMUSG00000001847 and 19353, RAC1 and IDBG-641023 and ENSBTAG00000009233 and 281440
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Gene info
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Identity
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Gene
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Long gene nameRac family small GTPase 1
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Synonyms gene name
- ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
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Synonyms
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GenBank acession
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Locus
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Discovery year1993-11-05
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Rho family GTPases
- Receptor ligands
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameribonuclease A family member 1, pancreatic
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Synonyms gene
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Synonyms gene name
- ribonuclease, RNase A family, 1 (pancreatic)
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Synonyms
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GenBank acession
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Locus
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Discovery year1990-02-24
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Entrez gene record
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Pubmed identfication
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Classification
- Ribonuclease A family
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data