Rabbit Anti Human LRP8 Antibody-Non-conjugated

• Catalog number
  CSB-PA623900LA01HU_50ug
• Price
  Please ask
• Size
  50ug

• Long name
  Rabbit Antibody against Human LRP8, Non-conjugated
• Synonym name
  LRP8 Human Antibody
• Species reactivity
  Human
• Tested applications recommended dilutions
  ELISA,WB,IF;Recommended dilution:WB:1:500-1:5000,IF:1:50-1:200
• Conjugation
  Non-conjugated
• Antibody isotype
  IgG
• UniProt ID
  Q14114
• Format
  Liquid, diluted in buffer
• Buffer composition
  Preservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Purity
  >95%
• Purification method
  Protein G purified
• Antibody category
  Polyclonal Antibodies
• Immunogen type
  Recombinant Human Low-density lipoprotein receptor-related protein 8 protein (131-332AA)
• Immunogen species
  Human
• Alias
  Low-density lipoprotein receptor-related protein 8,LRP-8,Apolipoprotein E receptor 2,LRP8,APOER2
• Background
  Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor.
• Clonality
  Polyclonal antibody
• Shipping and storage
  LRP8 Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
• Short name of the antigen
  Low-density lipoprotein receptor-related protein 8
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
• Properties
  If you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• About
  Rabbits are used for polyclonal antibody production by Cusabio. Rabbit antibodies are very stable and can be stored for several days at room temperature. Cusabio adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
• Latin name
  Oryctolagus cuniculus
• French translation
  anticorps

• Gene target
  LRP8   Non-conjugated  
• Gene symbol
  LRP8-DT, LRP8
• Short name
  Anti-LRP8
• Technique
  anti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for, antibody Conjugates
• Host
  Rabbit, Rabbits
• Species
  Human, Humans
• Alternative name
  LRP8 Antibody
• Alternative technique
  antibodies, rabbit-anti
• Alternative to gene target
  low density lipoprotein receptor-related protein 8, apolipoprotein e receptor, APOER2 and HSZ75190 and LRP-8 and MCI1, LRP8 and IDBG-98740 and ENSG00000157193 and 7804, reelin receptor activity, Extracellular, Lrp8 and IDBG-171850 and ENSMUSG00000028613 and 16975, LRP8 and IDBG-639215 and ENSBTAG00000000736 and

Gene info

• Identity
  HGNC:52561
• Gene
  LRP8-DT
• Long gene name
  LRP8 divergent transcript
• Synonyms gene
  • LINC01771
• Synonyms gene name
  • long intergenic non-protein coding RNA 1771
• Locus
  1p32.3
• Discovery year
  2016-11-08
• Entrez gene record
  105378732
• RefSeq identity
  • NR_131923
• Classification
  • Divergent transcripts
• VEGA ID
  OTTHUMG00000008948

Gene info

• Identity
  HGNC:6700
• Gene
  LRP8
• Long gene name
  LDL receptor related protein 8
• Synonyms gene name
  • low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
• Synonyms
  • APOER2
  • MCI1
  • LRP-8
  • HSZ75190
• GenBank acession
  • D50678
• Locus
  1p32.3
• Discovery year
  1998-08-13
• Entrez gene record
  7804
• Pubmed identfication
  • 8626535
  • 9079678
• RefSeq identity
  • NM_004631
• Classification
  • Low density lipoprotein receptors
• VEGA ID
  OTTHUMG00000008924

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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