Rabbit Anti Human KLRK1 Antibody-Non-conjugated
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Catalog numberCSB-PA012474LA01HU_100ug
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PricePlease ask
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Size100ug
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Long nameRabbit Antibody against Human KLRK1, Non-conjugated
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Synonym nameKLRK1 Human Antibody
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Species reactivityHuman
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Tested applications recommended dilutionsELISA,WB,IHC,IF;Recommended dilution:WB:1:200-1:5000,IHC:1:20-1:200,IF:1:50-1:200
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ConjugationNon-conjugated
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Antibody isotypeIgG
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UniProt IDP26718
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FormatLiquid, diluted in buffer
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Buffer compositionPreservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
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Purity>95%
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Purification methodProtein G purified
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Antibody categoryPolyclonal Antibodies
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Immunogen typeRecombinant Human NKG2-D type II integral membrane protein (73-216AA)
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Immunogen speciesHuman
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AliasNKG2-D type II integral membrane protein,Killer cell lectin-like receptor subfamily K member 1,NK cell receptor D,NKG2-D-activating NK receptor,CD314,KLRK1,D12S2489E,NKG2D
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BackgroundFunction as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
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ClonalityPolyclonal antibody
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Shipping and storageKLRK1 Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
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Short name of the antigenNKG2-D type II integral membrane protein
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
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PropertiesIf you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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AboutRabbits are used for polyclonal antibody production by Cusabio. Rabbit antibodies are very stable and can be stored for several days at room temperature. Cusabio adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin nameOryctolagus cuniculus
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French translationanticorps
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Gene target
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Gene symbolKLRC4-KLRK1, KLRK1-AS1, KLRK1
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Short nameAnti-KLRK1
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Techniqueanti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for, antibody Conjugates
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HostRabbit, Rabbits
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SpeciesHuman, Humans
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Alternative nameKLRK1 Antibody
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Alternative techniqueantibodies, rabbit-anti
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Alternative to gene targetNKG2-D type II integral membrane protein, CD314 and D12S2489E and KLR and NKG2-D and NKG2D, KLRK1 and IDBG-546188 and ENSG00000255819 and 100528032,22914, multiple
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Gene info
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Identity
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Gene
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Long gene nameKLRC4-KLRK1 readthrough
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Locus
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Discovery year2013-09-25
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Entrez gene record
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameKLRK1 antisense RNA 1
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Synonyms
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Locus
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Discovery year2020-04-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Antisense RNAs
Gene info
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Identity
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Gene
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Long gene namekiller cell lectin like receptor K1
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Synonyms gene
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Synonyms gene name
- DNA segment on chromosome 12 (unique) 2489 expressed sequence
- killer cell lectin-like receptor subfamily K, member 1
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Synonyms
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GenBank acession
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Locus
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Discovery year2003-12-12
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Killer cell lectin like receptors
- C-type lectin domain containing
- CD molecules
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data