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Long name
Rabbit Antibody against Human ITPR1, Biotin
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Synonym name
ITPR1 Human Antibody
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Species reactivity
Human
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Tested applications recommended dilutions
ELISA
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Conjugation
Biotin
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Antibody isotype
IgG
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UniProt ID
Q14643
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Format
Liquid, diluted in buffer
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Buffer composition
Preservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
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Purity
>95%
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Purification method
Protein G purified
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Antibody category
Polyclonal Antibodies
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Immunogen type
Recombinant Human Inositol 1,4,5-trisphosphate receptor type 1 protein (1707-1966AA)
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Immunogen species
Human
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Alias
Inositol 1,4,5-trisphosphate receptor type 1,IP3 receptor isoform 1,IP3R 1,InsP3R1,Type 1 inositol 1,4,5-trisphosphate receptor,Type 1 InsP3 receptor,ITPR1,INSP3R1
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Background
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate (PubMed:27108797). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).
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Clonality
Polyclonal antibody
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Shipping and storage
ITPR1 Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
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Short name of the antigen
Inositol 1,4,5-trisphosphate receptor type 1
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
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Properties
If you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Biotin conjugates can be detected by horseradish peroxidase, alkaline phosphatase substrates or anti biotin conjugated antibodies. Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA. To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1.6. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional conjugation
Biotinylated
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About
Rabbits are used for polyclonal antibody production by Cusabio. Rabbit antibodies are very stable and can be stored for several days at room temperature. Cusabio adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin name
Oryctolagus cuniculus
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French translation
anticorps
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Gene target
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Gene symbol
ITPR1-DT, ITPR1
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Short name
Anti-ITPR1
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Technique
anti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for
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Host
Rabbit, Rabbits
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Label
Biotin
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Species
Human, Humans
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Alternative name
ITPR1 Antibody,Biotin conjugated
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Alternative technique
antibodies, rabbit-anti
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Alternative to gene target
inositol 1,4,5-trisphosphate receptor, type 1, ACV and CLA4 and INSP3R1 and IP3R and IP3R1 and PPP1R94 and SCA15 and SCA16 and SCA29, ITPR1 and IDBG-14187 and ENSG00000150995 and 3708, inositol 1, nuclei, Itpr1 and IDBG-174302 and ENSMUSG00000030102 and 16438, BT.22305 and IDBG-644817 and ENSBTAG00000020455 and 317697
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