Rabbit Anti Human C4B Antibody-Biotin
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Catalog numberCSB-PA313364LD01HU_100ug
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Price:Ask for price
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Size100ug
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Long nameRabbit Antibody against Human C4B, Biotin
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Synonym nameC4B Human Antibody
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Species reactivityHuman
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Tested applications recommended dilutionsELISA
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ConjugationBiotin
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Antibody isotypeIgG
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UniProt IDP0C0L5
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FormatLiquid, diluted in buffer
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Buffer compositionPreservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
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Purity>95%
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Purification methodProtein G purified
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Antibody categoryPolyclonal Antibodies
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Immunogen typeRecombinant human Complement C4-B protein (1454-1744AA)
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Immunogen speciesHuman
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AliasBasic complement C4,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3,CO4, CPAMD3,C4B,C4B_2
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BackgroundNon-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Ref.16 Ref.17 Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
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ClonalityPolyclonal antibody
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Shipping and storageC4B Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
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PropertiesIf you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Biotin conjugates can be detected by horseradish peroxidase, alkaline phosphatase substrates or anti biotin conjugated antibodies. Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA. To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1.6. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional conjugationBiotinylated
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AboutRabbits are used for polyclonal antibody production by Cusabio. Rabbit antibodies are very stable and can be stored for several days at room temperature. Cusabio adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin nameOryctolagus cuniculus
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French translationanticorps
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Gene target
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Gene symbolC4B-AS1, C4B, C4A
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Short nameAnti-C4B
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Techniqueanti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for
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HostRabbit, Rabbits
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LabelBiotin
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SpeciesHuman, Humans
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Alternative nameC4B Antibody,Biotin conjugated
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Alternative techniqueantibodies, rabbit-anti
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Alternative to gene targetcomplement component 4B (Chido blood group), C4B_2 and C4B1 and C4B12 and C4B2 and C4B3 and C4B5 and C4BD and C4F and CH and CO4 and CPAMD3, C4B and IDBG-301132 and ENSG00000224389 and 100293534,721, carbohydrate binding, Extracellular
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Gene info
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Identity
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Gene
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Long gene nameC4B antisense RNA 1
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Synonyms gene name
- C4B antisense RNA 1 (non-protein coding)
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Locus
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Discovery year2011-04-21
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Classification
- Antisense RNAs
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namecomplement C4B (Chido blood group)
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Synonyms gene name
- complement component 4B
- complement component 4B (Chido blood group)
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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RefSeq identity
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Classification
- C3 and PZP like, alpha-2-macroglobulin domain containing
- Blood group antigens
- Complement system activation components
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namecomplement C4A (Rodgers blood group)
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Synonyms gene name
- complement component 4A
- complement component 4A (Rodgers blood group)
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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RefSeq identity
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Classification
- C3 and PZP like, alpha-2-macroglobulin domain containing
- Blood group antigens
- Complement system activation components
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
