Rabbit Anti Human BUB1B Antibody-Non-conjugated
-
Catalog numberCSB-PA002883LA01HU_50ug
-
PricePlease ask
-
Size50ug
-
-
Long nameRabbit Antibody against Human BUB1B, Non-conjugated
-
Synonym nameBUB1B Human Antibody
-
Species reactivityHuman
-
Tested applications recommended dilutionsELISA,IHC,IF;Recommended dilution:IHC:1:20-1:200,IF:1:50-1:200
-
ConjugationNon-conjugated
-
Antibody isotypeIgG
-
UniProt IDO60566
-
FormatLiquid, diluted in buffer
-
Buffer compositionPreservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
-
Purity>95%
-
Purification methodProtein G purified
-
Antibody categoryPolyclonal Antibodies
-
Immunogen typeRecombinant human Mitotic checkpoint serine/threonine-protein kinase BUB1 beta protein (230-394AA)
-
Immunogen speciesHuman
-
AliasMitotic checkpoint serine/threonine-protein kinase BUB1 beta,MAD3/BUB1-related protein kinase,hBUBR1,Mitotic checkpoint kinase MAD3L,Protein SSK1,BUB1B,BUBR1,MAD3L,SSK1
-
BackgroundEssential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.
-
ClonalityPolyclonal antibody
-
Shipping and storageBUB1B Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
-
Short name of the antigenMitotic checkpoint serine/threonine-protein kinase BUB1 beta
-
DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
-
PropertiesIf you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
-
AboutRabbits are used for polyclonal antibody production by Cusabio. Rabbit antibodies are very stable and can be stored for several days at room temperature. Cusabio adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
-
Latin nameOryctolagus cuniculus
-
French translationanticorps
-
Gene target
-
Gene symbolBUB1B-PAK6, BUB1B
-
Short nameAnti-BUB1B
-
Techniqueanti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for, antibody Conjugates
-
HostRabbit, Rabbits
-
SpeciesHuman, Humans
-
Alternative nameBUB1B Antibody
-
Alternative techniqueantibodies, rabbit-anti
-
Alternative to gene targetbudding uninhibited by benzimidazoles 1 homolog beta (yeast), Bub1A and BUB1beta and BUBR1 and hBUBR1 and MAD3L and MVA1 and SSK1, BUB1B and IDBG-6103 and ENSG00000156970 and 701, transferase activity, nuclei, Bub1b and IDBG-198179 and ENSMUSG00000040084 and 12236, BT.25661 and IDBG-646208 and ENSBTAG00000007237 and 100851213,537027
-
Gene info
-
Identity
-
Gene
-
Long gene nameBUB1B-PAK6 readthrough
-
Locus
-
Discovery year2017-01-23
-
Entrez gene record
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameBUB1 mitotic checkpoint serine/threonine kinase B
-
Synonyms gene name
- budding uninhibited by benzimidazoles 1 (yeast homolog), beta
- budding uninhibited by benzimidazoles 1 homolog beta (yeast)
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1998-03-25
-
Entrez gene record
-
Pubmed identfication
-
VEGA ID
-
Locus Specific Databases
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data