Rabbit Anti Human BAP1 Antibody-Non-conjugated
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Catalog numberCSB-PA849763ESR2HU_50ul
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PricePlease ask
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Size50ul
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Long nameRabbit Antibody against Human BAP1, Non-conjugated
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Synonym nameBAP1 Human Antibody
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Species reactivityHuman
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Tested applications recommended dilutionsELISA,WB;Recommended dilution:WB:1:200-1000
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ConjugationNon-conjugated
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Antibody isotypeIgG
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UniProt IDQ92560
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FormatLiquid, diluted in buffer
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Buffer compositionPBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Purity>95%
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Purification methodAntigen Affinity Purified Antibodies
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Antibody categoryPolyclonal Antibodies
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Immunogen typeRecombinant human Protein BANP protein (460-729AA)
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Immunogen speciesHuman
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AliasBRCA1-associated protein 1,Cerebral protein 6,BAP1,KIAA0272,hucep-6
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BackgroundDeubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Acts as a tumor suppressor.
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ClonalityPolyclonal antibody
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Shipping and storageBAP1 Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
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PropertiesIf you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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AboutRabbits are used for polyclonal antibody production by Cusabio. Rabbit antibodies are very stable and can be stored for several days at room temperature. Cusabio adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin nameOryctolagus cuniculus
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French translationanticorps
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Gene target
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Gene symbolBAP1, MAGI1, RNF2
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Short nameAnti-BAP1
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Techniqueanti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for, antibody Conjugates
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HostRabbit, Rabbits
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SpeciesHuman, Humans
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Alternative nameBAP1 Antibody
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Alternative techniqueantibodies, rabbit-anti
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Gene info
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Identity
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Gene
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Long gene nameBRCA1 associated protein 1
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Synonyms gene name
- BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1998-09-17
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Entrez gene record
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Pubmed identfication
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Classification
- Ubiquitin C-terminal hydrolases
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namemembrane associated guanylate kinase, WW and PDZ domain containing 1
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Synonyms gene
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Synonyms gene name
- BAI1-associated protein 1
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-09-29
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Membrane associated guanylate kinases
- PDZ domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namering finger protein 2
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Synonyms
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GenBank acession
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Locus
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Discovery year1997-06-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Ring finger proteins
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
