Human Thyroid hormone receptor beta (THRB)
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Catalog numberCSB-EP023514HU-500ug
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Price:
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Size500ug
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DescriptionRecombinant Human Thyroid hormone receptor beta(THRB) expressed in E.coli
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SpecificationsUniprot ID: P10828; Host: Homo sapiens (Human); Expression system: E.coli; Expression region: 1-461aa; Sequence information: Full Length; Tag: N-terminal 6xHis-SUMO-tagged; Purity: Greater than 90% as determined by SDS-PAGE.
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Additional_informationMW: 68.8 kDa; Buffer composition: Tris-based buffer with 50% glycerol.
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Storage_and_shippingShipped on ice packs (+4°C). The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. Repeated freezing and thawing should be avoided. Store working aliquots at 4°C for up to one week.
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NotesFor research use only.
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Additional descriptionHormone releasing factors and releasing hormones are signaling molecules produced by glands in multicellular organisms. The glands that secrete Luteinizing hormones LHRG and LH, FSH comprise the endocrine signaling system. The term growth hormone releasing hormone GHRH is sometimes extended to include chemicals produced by cells that affect the same cell (autocrine or intracrine signaling) or nearby cells (paracrine signaling). Human recombinant LHRG and GHRH are produced in E. coli or in yeast cells. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Gene target
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Gene symbolTHRB-AS2, THRB-IT1, THRB-AS1, THRB
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Short nameThyroid hormone receptor beta (THRB)
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SpeciesHuman, Humans
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Alternative nameH. sapiens Thyroid hormone receptor b (thyroid hormone receptor, b)
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Alternative to gene targetthyroid hormone receptor, beta, C-ERBA-2 and C-ERBA-BETA and ERBA2 and GRTH and NR1A2 and PRTH and THR1 and THRB1 and THRB2, THRB and IDBG-22332 and ENSG00000151090 and 7068, thyroid hormone binding, nuclei, Thrb and IDBG-133569 and ENSMUSG00000021779 and 21834, THRB and IDBG-630420 and ENSBTAG00000017802 and 788329
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Tissuethyroid
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Gene info
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Identity
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Gene
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Long gene nameTHRB antisense RNA 2
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Locus
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Discovery year2020-02-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Antisense RNAs
Gene info
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Identity
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Gene
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Long gene nameTHRB intronic transcript 1
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Synonyms gene name
- THRB intronic transcript 1 (non-protein coding)
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Locus
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Discovery year2011-05-19
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Classification
- Intronic transcripts
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameTHRB antisense RNA 1
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Locus
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Discovery year2012-11-14
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Entrez gene record
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RefSeq identity
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Classification
- Antisense RNAs
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namethyroid hormone receptor beta
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Synonyms gene
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Synonyms gene name
- thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2)
- pituitary resistance to thyroid hormone
- thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
- thyroid hormone receptor, beta
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Synonyms
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Synonyms name
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Locus
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Discovery year1988-08-31
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Thyroid hormone receptors
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VEGA ID